YI-SHUAN SHEENCHIA-YU CHUWang S.-H.TSEN-FANG TSAI2019-12-042019-12-0420090954-6634https://www.scopus.com/inward/record.uri?eid=2-s2.0-72449164512&doi=10.3109%2f09546630802691317&partnerID=40&md5=6bd9301f677134abeb2626b47bdb5948https://scholars.lib.ntu.edu.tw/handle/123456789/434712Background: Dapsone hypersensitivity syndrome (DHS) is a potentially life-threatening adverse drug reaction consisting of fever, hepatitis, exfoliative dermatitis, lymphadenopathy and hemolytic anemia. The incidence of DHS is estimated to be 2% in leprosy patients. Because the incidence of this drug eruption may be different in different ethnicities and diseases, we thought to investigate the incidence of DHS in non-leprosy patients. Methods: This is a retrospective study to examine the incidence, clinical manifestations and prognosis of DHS in non-leprosy patients who were given dapsone at the National Taiwan University Hospital between June 2001 and December 2005. Results: The incidence of DHS among non-leprosy patients was 1.66%. These patients ran a relatively benign course as compared with leprosy patients. Conclusion: The incidence of DHS among non-leprosy patients was compatible to that observed among leprosy patients. DHS in non-leprosy patients runs a favorable course with low morbidity in our study. ? 2008 Informa UK Ltd.[SDGs]SDG3corticosteroid; dapsone; adolescent; adult; aged; alkaline phosphatase blood level; article; child; clinical feature; controlled study; DRESS syndrome; drug withdrawal; female; foot edema; hepatosplenomegaly; human; human tissue; hypoalbuminemia; incidence; leprosy; leukocytosis; liver injury; lymphadenopathy; lymphocytosis; maculopapular rash; major clinical study; male; morbidity; papulovesicular rash; preschool child; priority journal; prognosis; school child; side effect; Taiwan; Adolescent; Adult; Aged; Aged, 80 and over; Anemia, Hemolytic; Child; Child, Preschool; Dapsone; Dermatitis, Exfoliative; Drug Hypersensitivity; Drug-Induced Liver Injury; Female; Fever; Hospitals, Teaching; Humans; Incidence; Inpatients; Leprostatic Agents; Lymphatic Diseases; Male; Middle Aged; Retrospective Studies; Skin Diseases; Syndrome; Taiwanjournal article10.3109/09546630802691317199543902-s2.0-72449164512