精神科LIU, CHIH-MINCHIH-MINLIUHWU, HAI-GWOHAI-GWOHWU2008-12-082018-07-122008-12-082018-07-122002http://ntur.lib.ntu.edu.tw//handle/246246/89615Linkage evidence of schizophrenia to markers at chromosome 22q11-13 were reported in several studies.We intended to evaluate linkage evidence of schizophrenia to chromosome 22q 11-13 in 106 Taiwanese schizophrenic families with at least two affected siblings. Two phenotype models (narrow : DSM-IV schizophrenia only; and broad: including schizophrenia, schizoaffective, and other non-affective psychotic disorders ) were used to define the disease phenotype. To this date, we have genotyped 3 microsatellite markers over this region. Maximum non-parametric linkage ( NPL) scores of 1.53 (P&frac 14;0.05) and 1.04 (P¼0.14) were obtained at the marker D22S156 under broad and narrow model, respectively. The marker is near the distal part of the 22q microdeletion region.We are continuing to genotype more markers at the proximal side, in the 22q microdeletion region.en-US