Chen C.-J.PING-ING LEEHsieh Y.-C.Chen P.-Y.Ho Y.-H.Chang C.-J.DING-PING LIUChang F.-Y.Chiu C.-H.Huang Y.-C.Lee C.-Y.Lin T.-Y.2021-01-072021-01-0720120264-410Xhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84867483656&doi=10.1016%2fj.vaccine.2012.05.019&partnerID=40&md5=e2bac7db068ab47c1daf05676ed0224chttps://scholars.lib.ntu.edu.tw/handle/123456789/539550To evaluate the population immunity to measles in Taiwan where the coverage rate of the measles vaccine was >95% for more than a decade, anti-measles IgG was determined in 3552 Taiwanese volunteers in 2007. The overall seroprevalence was 74.7% (95% confidence interval [CI]: 73.3-76.1%). In subgroups aged 2-25 years, to whom at least 2 doses of measles-containing vaccine were given, there was a declining trend of seropositivity with age from 94.5% at 2 years to 50.6% at 21-25 years (p<0.0001). Age (odds ratio [OR]: 1.0464, 95% CI: 1.043-1.085) and male gender (OR: 1.466, 95% CI: 1.131-1.901) were independent factors predicting seronegative sera in this population. Seroprevalence was uniformly >95% in the older population (?35 years) who had not been immunized against measles. The waning vaccine-induced immunity may have impact on the control of measles in the future, especially when the vaccinated population becomes older. ? 2012.[SDGs]SDG3immunoglobulin G; measles vaccine; article; female; human; immunity; major clinical study; male; measles; population research; priority journal; seroprevalence; Taiwan; Adolescent; Adult; Age Factors; Aged; Antibodies, Viral; Child; Child, Preschool; Female; Humans; Immunity, Herd; Infant; Male; Measles; Measles Vaccine; Middle Aged; Seroepidemiologic Studies; Taiwan; Young Adultjournal article10.1016/j.vaccine.2012.05.019226342942-s2.0-84867483656