Feng C.-Y.WEN-MING HSUChen Y.2020-03-052020-03-0520010929-6646https://www.scopus.com/inward/record.uri?eid=2-s2.0-0035022108&partnerID=40&md5=616072a1ec91a94694267b272116e658https://scholars.lib.ntu.edu.tw/handle/123456789/470075We describe a case of perforated peptic ulcer (PPU) in a 9-month-old boy. Abdominal distension was the first clinical sign of PPU. Before he developed abdominal distension, the patient had suffered from an upper respiratory tract infection with fever for about 2 weeks, which was treated intermittently with ibuprofen. A plain abdominal radiograph revealed pneumoperitioneum with a football sign. At laparotomy, a 0.8-cm perforated hole was found over the prepyloric area. Simple closure with omental patching was performed after debridement of the perforation. Pathologic examination showed chronic peptic ulcer with Helicobacter pylori infection. The postoperative course and outcome were satisfactory. The stress of underlying disease, use of ibuprofen, blood type (A), and H. pylori infection might have contributed to the development of PPU in this patient. PPU in infancy is rare and has a high mortality rate; early recognition and prompt surgical intervention are key to successful management.Helicobacter pylori; Infant; Non-steroidal anti-inflammatory drug; Perforated peptic ulcer[SDGs]SDG3cisapride; ibuprofen; abdominal distension; abdominal radiography; abnormal respiratory sound; article; blood group A; blood pressure; case report; debridement; drug intermittent therapy; emergency surgery; fever; Gram negative infection; Helicobacter pylori; histopathology; human; infant; laparotomy; leukocytosis; male; peptic ulcer; pneumoperitoneum; postoperative period; pylorus; stomach emptying; ulcer perforation; upper respiratory tract infection; Humans; Infant; Male; Peptic Ulcer Perforationjournal article113931012-s2.0-0035022108