Hwang L.-H.PEI-MING YANGLai M.-Y.BOR-LUEN CHIANGJIA-HORNG KAOWang, Jin-TownJin-TownWangLee S.-Y.Chian H.-M.Chi W.-K.Chu Y.-D.PEI-JER CHENDING-SHINN CHEN2019-09-022019-09-0219960022-1899https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984564143&doi=10.1093%2finfdis%2f174.1.173&partnerID=40&md5=4efa74b666d710c36421f5cfd0c80616https://scholars.lib.ntu.edu.tw/handle/123456789/417231Immunoblot analysis on serum samples from 90 patients with chronic hepatitis C virus infection revealed four putative immunogenic regions within the NS3 protein of the virus: E (around aa 1250/1251), A (within aa 1250- 1334), A/B (around aa 1323 and 1334), and B/C (around aa 1407 and 1412). Among them, region E was most immunodominant, and region A was recognized much less frequently by patients with cirrhosis than by those with chronic hepatitis (10% vs. 46%, χ2 = 12.05. P < .01). The results suggest that region A might be a potential prognostic marker to differentiate chronic hepatitis from cirrhosis.en-US[SDGs]SDG3virus antigen; virus protein; adult; antigen recognition; article; controlled study; hepatitis C; Hepatitis C virus; human; humoral immunity; immunoblotting; liver cirrhosis; major clinical study; priority journal; prognosisjournal article10.1093/infdis/174.1.17386559882-s2.0-84984564143