Yeh Y.-C.Kim S.T.Tang R.Yan B.Rotello V.M.YI-CHEUN YEH2019-09-262019-09-26201420507518https://scholars.lib.ntu.edu.tw/handle/123456789/425371Effective regulation of nanoparticle (NP) uptake facilitates the NP-based therapeutics and diagnostics. Here, we report the use of insulin and 2-deoxyglucose (2-DG) to modulate the cellular uptake of glucose-functionalized quantum dots (Glc-QDs) in C2C12 muscle cells. The cellular uptake of Glc-QDs can be modulated up to almost two-fold under insulin stimulation while be down-regulated in the presence of 2-DG. These results demonstrate the use of secondary regulators to control the cellular uptake of NPs through membrane protein recognition in a specific and fine-tunable fashion. ? 2014 the Partner Organisations.journal article10.1039/c4tb00608a2-s2.0-84903760948https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84903760948&doi=10.1039%2fc4tb00608a&partnerID=40&md5=67e84d00dd4ed2eb1bda42d9d1561b9a