2020-04-152024-05-14https://scholars.lib.ntu.edu.tw/handle/123456789/661460摘要：由於現有之傳統廢水處理系統無法有效去除藥物和個人保健用品等新興污染物，像恩菎類廣效抗生素環丙沙星之化合物可能會存在於環境水體中，並可能對人體健康及環境造成潛在威脅。美國食品藥物管理局 (Food and drug administration, FDA) 已將恩菎類藥物加入黑盒子警示 (Black Box Warning)，而歐盟 (European Medicines Agency, EMA) 藥物安全監測與風險評估委員會 (Pharmacovigilance Risk Assessment Committee, PRAC) 指出此類藥物可能導致長期副作用並建議其下架，因此針對這類藥物與其降解過程中產生之轉化副產物，可能對土壤與水環境中造成不良風險引起高度關注。電化學系統係藉由電流通過電極時，陰極與陽極分別形成還原及氧化反應，加上其簡單的流程、設備與低成本的材料，此系統較傳統廢水處理系統可更廣泛應用於去除不同類型之污染物。本研究計畫使用電化學系統去除水中恩菎類廣效抗生素環丙沙星，並針對可能影響去除效率之操作參數進行系統性地研究，如初始pH值、電流密度、初始藥物濃度、電解質種類及濃度等。最後，亦會考慮實際廢水中的基質影響，並更進一步地探討反應機制與其過程產生之中間產物及可能的降解途徑。<br> Abstract: The quinolone antibiotic ciprofloxacin (CIP) is pharmaceuticals and personal care products (PPCPs), which might create potential threats for human health and the environment. All the contaminants are becoming enormous in the environment as conventional wastewater treatment cannot be effectively eliminated due to toxic and complicated substances. According to the U.S. Food and Drug Administration (FDA) and the European Medicines Agency’s (EMA) Pharmacovigilance Risk Assessment Committee (PRAC) announcement, fluoroquinolone and quinolone antibiotics are added to the Black Box Warning, which should be disabling, and might have potentially long-lasting side effects. For these reasons, the existence of PPCPs has brought high awareness, causing significant concern on their occurrence, risk, transformation products, and degradation pathway in the soil and aquatic environments. The electrochemical process (EC) is effectively applied for the removal of contaminants, pharmaceuticals, and various kinds of pollutants. During the EC process, the cathode and anode containing both reduction and oxidation, respectively, while electric current passed through the electrodes. Due to the simple procedure, equipment, and less costly material, EC system is extensively recognized for pharmaceuticals wastewater treatment over further conventional treatment processed. The electrochemical removal of quinolone antibiotic ciprofloxacin was investigated in aqueous solutions. The operational parameters influencing EC efficiency are systemically investigated for the optimization of the removal of CIP, such as initial pH, current density, initial pharmaceutical concentration, concentration and types of electrolyte. Finally, to clarify the specific mechanism in the real scenario, the variation of CIP during the electrochemical oxidation process and to identify the factors affecting such variation were discussed. Furthermore, to investigate the generation of intermediates during the reaction, the mechanism and intermediate pathways were also investigated.電化學氧化法白金鈦板恩菎類廣效抗生素Electrochemical oxidation (EO)Pt/Ti electrodeQuinolone Antibiotic