Huang C.-C.FEN-YU TSENGTE-HUEI YEHWen Y.-H.Hsu C.-J.JENG-YUH KOPEI-JEN LOUChen Y.-S.2020-06-012020-06-0120080194-5998https://www.scopus.com/inward/record.uri?eid=2-s2.0-49549125675&doi=10.1016%2fj.otohns.2008.05.015&partnerID=40&md5=2048eea246205e6cca27999149898e91https://scholars.lib.ntu.edu.tw/handle/123456789/495476Objective: To evaluate the prognostic factors of unknown primary head and neck squamous cell carcinoma (HNSCC). Study Design: Retrospective study. Subjects: Patients with unknown primary HNSCC from 1980 to 2000 were included. Results: Forty-eight patients, predominantly male and with a mean age of 63.3 ± 11.6 years, were recruited. The median survival time (MST) was 44 months. The overall survival rate was 60.4 percent at three years and 39.6 percent at five years. Forty-two patients receiving intervention regimens had a MST of 45 months, while six patients receiving palliative therapy had a MST of 8.5 months (log rank test, P = 0.016). With multivariate Cox regression analysis, age (per year), higher nodal stage (N3 vs N1 or N2), and treatment (operation vs nonoperation) had a hazard ratio of 1.081 (P < 0.0001), 5.852 (P = 0.010), and 0.4 (P = 0.042), respectively. Conclusion: Older age, higher nodal stage, and palliative treatment indicated poor prognosis. Survival time might be prolonged if surgical treatment is tolerable. ? 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation.[SDGs]SDG3adult; aged; article; cancer chemotherapy; cancer radiotherapy; cancer staging; clinical article; controlled study; female; hazard ratio; head and neck carcinoma; human; intervention study; log rank test; male; multivariate logistic regression analysis; neck dissection; overall survival; palliative therapy; prognosis; proportional hazards model; retrospective study; senescence; squamous cell carcinoma; statistical significance; survival rate; survival time; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasms, Unknown Primary; Prognosis; Survival Analysisjournal article10.1016/j.otohns.2008.05.015187222262-s2.0-49549125675