2006-06-232024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/683821摘要：我國食藥用之特用作物資源具豐富的生物多樣性。面對國際上對保育生物多樣性、永續利用其組成，以及公平合理的分享等壓力，除了必須保存這些生物種類、延續物種基因之遺傳多樣性之外，也必須研究開發這些資源的附加價值例如生理機能性等。 本子計畫計畫以四年期間研究我國本土食藥用蕈菇類資源的生物多樣性，尋找適切的生理活性指標物質 (biomarker)，開發具機能保健潛力的資源物種，將可落實瞭解我國食藥用特用作物資源的生物多樣性，並促進資源的永續利用及相關產業的永續發展。本年度之目標包括: 1. 調查與純化一種以上之我國蕈菇類免疫調節蛋白。2. 建立以硫酸銨劃分層析與因陽離子交換吸附為基礎之產業用大量製備我國蕈菇類免疫調節蛋白之方法，對象包括金針菇免疫調節蛋白 FIP-FVE, 茯苓蛋白 PCP, 銀耳蛋白 TFPs, 並擇一建立工業化純化我國蕈菇類免疫調節蛋白之 pilot 先導模式。 3. 探討我國蕈菇類免疫調節蛋白活性區分物與精細純化物之生理活性差距。 <br> Abstract: Biodiversity resources of edible and medical herbs in Taiwan are rich and potential. Besides conserving these species, it is much important to investigate their additional value such as their physiological functionality. There are many herbs that have been reported to providing functional activities for various diseases in the literature. In Taiwan, species and resources of these medical herbs are numerous and potentially utilizable. Mushroom resources are typical examples. Some mushrooms are found to have the activities of modulating immune system, anticarcinogenicity and antimutagenicity. Unfortunately, little of studies were made to evaluate the biodiversity and applicability of these treasures. We plan to spend four years studying the biodiversity of edible/medical mushrooms in Taiwan. The objectives include to investigate the suitable biomarkers for evaluating their functionality, to determine their biomarker contents, and to evaluate the relationships between their genetic biodiversity and physiological activity. In this year, we would like to investigate and determine their biomarkers, including fungi immunomodulatory proteins and triterpenoids. The immunomodulatory effects and anticarcinogenicity of mushrooms would be studied. These results might be helpful to obtain potential mushroom and T. formosanum species for sustainable utilization in Taiwan.生物多樣性蕈菇類biodiversitymushroom