MING-SHIANG WUHuang S.-P.YU-TING CHANGCHIA-TUNG SHUNMING-CHU CHANGMING-TSAN LINHSIU-PO WANGLin J.-T.2020-03-232020-03-2320020022-1899https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036137221&doi=10.1086%2f324771&partnerID=40&md5=8616fbccfd5d341dc4e0ca49d4f33dbfhttps://scholars.lib.ntu.edu.tw/handle/123456789/477534To investigate whether genetic differences in cytokine promoter polymorphisms effect various outcomes after exposure to Epstein-Barr virus (EBV) infection, 30 patients with EBV-positive gastric carcinoma (GC), 120 patients with EBV-negative GC, and 220 control subjects were enrolled. Promoter polymorphisms of tumor necrosis factor (TNF)-α at positions -238 and -308 and of interleukin (IL)-10 at position -1082 were determined. The frequency of the high-producer allele (-308A) in the TNF-α gene was significantly higher among EBV-positive GC patients compared with control subjects (23.3% vs. 12.0%, P < .05), whereas the frequency of the high-producer allele (-1082G) in the IL-10 gene was significantly higher among EBV-negative GC patients compared with control subjects (6.3% vs. 3.0%, P < .05). These data support the notion that genetic factors may modify the outcomes of infectious diseases through different TNF-α- or IL-10-producing capabilities. ? 2002 Infectious Diseases Society of America.[SDGs]SDG3interleukin 10; tumor necrosis factor alpha; article; controlled study; disease association; disease course; DNA polymorphism; Epstein Barr virus; gene locus; human; infection sensitivity; major clinical study; pathogenesis; priority journal; stomach carcinoma; virus infection; Adenocarcinoma; China; Epstein-Barr Virus Infections; Gene Frequency; Humans; Interleukin-10; Polymorphism, Genetic; Promoter Regions (Genetics); Stomach Neoplasms; Taiwan; Tumor Necrosis Factor-alphajournal article10.1086/324771117569882-s2.0-0036137221