Yang, Y.-H.Y.-H.YangLiu, C.-H.C.-H.LiuLiang, Y.-H.Y.-H.LiangFENG-HUEI LINKEVIN CHIA-WEN WU2020-02-262020-02-262013https://scholars.lib.ntu.edu.tw/handle/123456789/463954Biocompatible and biodegradable hydroxyapatite nanoparticles with a hollow core and mesoporous shell structure (denoted as hmHANPs) are synthesized by an opposite ion core/shell strategy and applied to pH-responsive intracellular drug delivery systems (DDS). The synthesized hmHANPs have several advantages over solid hydroxyapatite nanoparticles (HANPs), where the hollow and mesoporous structure enhances drug-loading capacity, and the thin hydroxyapatite shell structure reduces burst release of drug and provides pH-responsive release. Doxorubicin (DOX), a therapeutic anticancer drug, was loaded in hmHANPs and HANPs for intracellular drug delivery systems (DDS). Compared to HANPs having a low drug-loading efficacy (17.9%), hmHANPs exhibited an excellent drug-loading efficacy (93.7%). In addition, the release amount of DOX from hmHANPs was 2.5-fold the amount from HANPs. Compared with free DOX, the anticancer efficacy of DOX-loaded hmHANPs was greatly enhanced, as evidenced by the results of MTT assays and confocal laser scanning microscopy using breast cancer cells (BT-20). The synthesized hmHANPs show great potential as drug nanovehicles with high biocompatibility, enhanced drug loading, and pH-responsive features for future intracellular DDS. ? The Royal Society of Chemistry 2013.[SDGs]SDG3Breast cancer cells; Confocal laser scanning microscopy; Hydroxyapatite nanoparticles; Intracellular drug delivery; Mesoporous hydroxyapatites; Mesoporous shell; Mesoporous structures; Release property; Biocompatibility; Drug delivery; Hydroxyapatite; Mesoporous materials; Nanoparticles; Synthesis (chemical); Loadingjournal article10.1039/c3tb20365d2-s2.0-84876894886https://www.scopus.com/inward/record.uri?eid=2-s2.0-84876894886&doi=10.1039%2fc3tb20365d&partnerID=40&md5=eeecfe50e13b40b3061c6c7899060c2d