2015-08-012024-05-14https://scholars.lib.ntu.edu.tw/handle/123456789/658536摘要：泌尿道上皮細胞癌源自於泌尿道之上皮細胞，可以出現在下泌尿道(例如膀胱或是尿道)或是上泌尿道(腎臟或輸尿管)。上泌尿道上皮細胞癌是一種罕見的癌症，只佔了所有泌尿道上皮細胞癌的百分之五到百分之十。在美國的發生率約為每十萬人有2.08人。不像膀胱癌，上泌尿道上皮細胞癌在初診斷時即有百分之四十的病人為侵襲性的。馬兜鈴酸為一腎毒性物質且為人類致癌物，和慢性腎病以及上泌尿道上皮細胞癌有相當關連。在台灣上泌尿道上皮細胞癌的發生率特高，可能與使用含有馬兜鈴酸的中藥有關。對於上泌尿道上皮細胞癌的傳統診斷方式包括斷層掃描、核磁共振、輸尿管鏡以及逆行性腎盂攝影。使用氟18-去氧葡萄糖的正子造影為一分子影像技術，且已經被廣泛應用於腫瘤領域。在正子造影對於泌尿道上皮細胞癌的研究中，大多數以膀胱癌為研究目標，而至今仍未有對於上泌尿道上皮細胞癌完整的研究被發表。本研究計畫使用氟18-去氧葡萄糖正子造影探討此技術對於上泌尿道上皮細胞癌的診斷、化學治療效果評估以及預測預後。<br> Abstract: Urothelial carcinoma is derived from the urothelium and can be located in the lower urinary tract (bladder and urethra) or the upper urinary tract (pyelocaliceal cavities and ureter). Upper urinary tract urothelial carcinoma (UTUC) is a rare disease and only accounts for 5-10% of all urothelial carcinoma. The estimated incidence in United States is 2.08 cases per 100000 person-years. Unlike bladder cancer, UTUC represents and aggressive disease with 40% are invasive at the diagnosis. Aristolochic acid is a nephrotoxin and human carcinogen associated with chronic kidney disease and UTUC. A high incidence of UTUC has been described in Taiwan, probably associated with aristolochic acid containing in Chinese herbal medicine. Conventional workup of UTUC includes computed tomography (CT), magnetic resonance imaging, diagnostic ureterosopy and retrograde pyelography. Positron emission tomography (PET) using 18F-fluorodeoxyglucose (FDG) is a molecule imaging technique and has been widely applied in oncology field. In urothelial carcinoma, most PET studies focus on the bladder cancer. At present, there is no published PET data applied in UTUC. In this study, we plan to use FDG-PET/CT to explore its role in UTUC, including detection of disease extent, evaluation of chemotherapy response and prediction of prognosis.上泌尿道上皮細胞癌氟18-去氧葡萄糖正子造影預後Upper urinary tract urothelial carcinomaFDGPETprognosis