CHUN-PIN CHIANGJULIA YU-FONG CHANGYI-PING WANGWu Y.-H.Wu Y.-C.ANDY SUN2021-07-072021-07-0720190929-6646https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061009826&doi=10.1016%2fj.jfma.2019.01.016&partnerID=40&md5=e0e41cadfb1d8a4fab14aea88e565af0https://scholars.lib.ntu.edu.tw/handle/123456789/570216Background/Purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) are organ-specific autoantibodies. This study mainly assessed the frequencies of presence of serum GPCA, TGA, and TMA in atrophic glossitis (AG) patients. Methods: Serum GPCA, TGA, and TMA levels were measured in 1064 AG patients and in 532 age- and sex-matched healthy control subjects. Results: We found that 26.7%, 28.4%, and 29.8% of 1064 AG patients and 2.3%, 2.1%, and 2.6% of 532 healthy control subjects had the serum GPCA, TGA, and TMA positivities, respectively. AG patients had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control subjects (all P-values < 0.001). We also found that 67 (6.3%), 181 (17.0%), and 340 (32.0%) AG patients and 3 (0.6%), 10 (1.9%), and 8 (1.5%) healthy control subjects had the presence of three (GPCA + TGA + TMA), two (GPCA + TGA, GPCA + TMA, or TGA + TMA), or one (GPCA only, TGA only, or TMA only) organ-specific autoantibody in their sera, respectively. Of 373 TGA/TMA-positive AG patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 78.6%, 8.0%, and 13.4% of these TGA/TMA-positive AG patients had normal, lower, and higher serum TSH levels, respectively. Conclusion: Approximately 55.3% of 1064 AG patients have serum GPCA/TGA/TMA positivity. Because part of GPCA-positive AG patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and part of TGA/TMA-positive AG patients may have thyroid dysfunction such as hyperthyroidism and hypothyroidism, these autoantibody-positive AG patients should be referred to medical doctors for further management. ? 2019 Formosan Medical Association[SDGs]SDG3microsome antibody; parietal cell antibody; thyroglobulin antibody; thyroid antibody; thyrotropin; autoantibody; thyroid microsomal antibodies; thyrotropin; adult; aged; antibody blood level; Article; atrophic glossitis; atrophy; controlled study; female; glossitis; human; immunofluorescence; major clinical study; male; measurement; stomach parietal cell; thyrotropin blood level; blood; case control study; complication; glossitis; hyperthyroidism; hypothyroidism; immunology; middle aged; pathophysiology; stomach parietal cell; thyroid gland; very elderly; young adult; Adult; Aged; Aged, 80 and over; Autoantibodies; Case-Control Studies; Female; Glossitis; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Parietal Cells, Gastric; Thyroid Gland; Thyrotropin; Young Adultjournal article10.1016/j.jfma.2019.01.016307369972-s2.0-85061009826