2013-01-012024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/694437摘要：黴菌毒素為黴菌產生之次級代謝物，對人體及畜禽均會產生嚴重的危害。穀物在採收前後均有可能受黴菌毒素污染，故其防範極為不易。而目前全球氣候暖化的結果，穀物受黴菌毒素污染的情形更為普遍。此外，大部份的黴菌毒素性質安定，加工後依然會殘留在食品或飼料中。畜禽食用受黴菌毒素污染的飼料將影響其生長繁殖性能，導致經濟上嚴重的損失。目前多以矽酸鋁或有機聚合物吸附飼料中的黴菌毒素，吸附法雖然可以減少黴菌毒素被動物吸收而降低其危害，但同時亦減少營養成分的吸收而導致飼料效率的降低。因此，尋求其他方法以解決穀物中黴菌毒素污染所致之危害，實有其必要性。目前已有許多研究證實土壤或腸道微生物具有分解黴菌毒素的能力，因此，本計畫擬自土壤或肉雞腸道微生物中篩選具有降解黃麴毒素能力的菌株，除進行菌種鑑定及黃麴毒素降解能力分析外，未來擬進一步將該菌株分別添加於一般肉雞飼料中或含黃麴毒素的肉雞飼料中，以評估其做為肉雞飼料用黃麴毒素解毒劑之可行性。<br> Abstract: Mycotoxins are toxin secondary metabolites produced by fungi. Most of them are heat-stable and cannot be destroyed by food and feed processing. The fact that contamination in grains can happen pre- and post-harvest makes it extremely difficult to control the spread of mycotoxins. Moreover, the change of global climate, such as “green-house effect”, has created an environment more favorable to the growth of some fungi. As a consequence, the economical loss associated with impaired animal health and performance due to consumption of mycotoxins has become a serious issue in the industry. Traditionally, elimination or reduction of contaminated mycotoxins in feed can be achieved by physical methods. The physical approaches are basically the addition of adsorbents, such aluminosilicate or organic polymers, into the feed to prevent mycotoxins absorbed by animals. Nevertheless, the binding capability of these adsorbents is not specific to mycotoxins, which may decrease the availability of soluble nutrients in digesta and reduce feed efficiency. Some soil and gastrointestinal microorganisms have been demonstrated to possess the ability to degrade mycotoxins. Therefore, this research aims at screening soil and gastrointestinal microorganisms that possess the ability to degrade aflatoxin. These aflatoxin-detoxifying bacterial strains will be added into broiler feed or aflatoxin-contaminated feed to evaluate their detoxifying ability.地衣芽孢桿菌微生物製劑黴菌毒素Bacillus licheniformismicrobial agentmycotoxin