CHUN-YI LUCHIN-YUN LEEPING-ING LEETsai H.-Y.Chiu T.-F.Lin H.-C.LI-MIN HUANG2021-06-242021-06-2419990929-6646https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033386422&partnerID=40&md5=6f0a337fb393f55b2d305f858fb9ed41https://scholars.lib.ntu.edu.tw/handle/123456789/566682Previous studies have shown that the immune response to trivalent oral poliovirus vaccine (OPV) varies widely from country to country. However, there has been no report on the immunogenicity of this vaccine in Taiwanese children. In this study, 98 children were followed up for 17 months to study the antibody responses following four doses of trivalent OPV. The results showed that, after two doses of vaccine, all children were protected against poliovirus type 1 and 2. All except two children also developed protective antibodies against poliovirus type 3. After three doses, the antibody levels in all subjects were above protective concentrations. The fourth dose, given at 18 months of age, further boosted the antibody titers. These findings show that the OPV currently used in Taiwan is highly immunogenic in Taiwanese children.[SDGs]SDG3oral poliomyelitis vaccine; antibody detection; antibody response; article; child; female; follow up; human; immunogenicity; male; normal human; poliomyelitis; Poliomyelitis virus; Taiwan; Antibodies, Viral; Female; Humans; Infant; Male; Poliovirus; Poliovirus Vaccine, Oral; Taiwanjournal article106340282-s2.0-0033386422