Su, Jui-HsinJui-HsinSuCHANG-FENG DAI2009-12-172018-06-282009-12-172018-06-282007http://www.scopus.com/inward/record.url?eid=2-s2.0-34147189948&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/330537http://ntur.lib.ntu.edu.tw/bitstream/246246/174452/1/68.pdfTwo new sesquiterpenoidal natural products chabrolidiones A and B (1 and 2), two C18 terpenoid-related carboxylic acids, ketochabrolic acid (3) and isoketochabrolic acid (4), and one naphthoquinone derivative chabrolonaphthoquinone C (5), along with two known compounds (+)-aristolone (6) and teuhetenone A (7) were isolated from a Formosan soft coral Nephthea chabrolii. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis and by comparison of NMR data with those of related metabolites. Metabolite 1 has been synthesized previously, but was isolated for the first time from natural sources. Cytotoxic activity of metabolites 1-3 and 5-7 against a limited panel of cancer cell lines is also described. ? 2007 Pharmaceutical Society of Japan.application/pdf140250 bytesapplication/pdfen-USNephthea chabrolii; Sesquiterpenoidal natural product; Soft coral[SDGs]SDG31,4 naphthoquinone derivative; aristolone; chabrolidione a; chabrolidione b; chabrolonaphthoquinone c; drug metabolite; isoketochabrolic acid; ketochabrolic acid; natural product; terpenoid; teuhetenone a; unclassified drug; article; cancer cell; carbon nuclear magnetic resonance; coral; cytotoxicity; drug isolation; drug structure; drug synthesis; human; IC 50; Nephthea chabrolii; nuclear magnetic resonance; nuclear Overhauser effect; proton nuclear magnetic resonance; Animals; Anthozoa; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Terpenesjournal article10.1248/cpb.55.5942-s2.0-34147189948WOS:000246377800018http://ntur.lib.ntu.edu.tw/bitstream/246246/174452/1/68.pdf