OWEN Y. CHAONikolaus, SusanneSusanneNikolausHuston, Joseph P.Joseph P.Hustonde Souza Silva, Maria A.Maria A.de Souza Silva2025-09-052025-09-052014-1010747427https://www.scopus.com/inward/record.uri?eid=2-s2.0-84903770837&doi=10.1016%2Fj.nlm.2014.06.009&partnerID=40&md5=ef8a14ff1263f28ef4e8c15ec8b5d726https://scholars.lib.ntu.edu.tw/handle/123456789/731856Senktide, a potent neurokinin-3 receptor (NK3-R) agonist, has been shown to have promnestic effects in adult and aged rodents and to facilitate episodic-like memory (ELM) in mice when administrated before the learning trial. In the present study we assessed the effects of senktide on memory consolidation by administering it post-trial (after the learning trial) in adult rats. We applied an ELM test, based on the integrated memory for object, place and temporal order, which we developed (Kart-Teke, de Souza Silva, Huston, & Dere, 2006). This test involves two learning trials and one test trial. We examined intervals of 1h and 23 h between the learning and test trials (experiment 1) in untreated animals and found that they exhibited intact ELM after a delay of 1 h, but not 23 h. In another test for ELM performed 7 days later, vehicle or senktide (0.2 mg/kg, s.c.) was applied immediately after the second learning trial and the test was conducted 23 h later (experiment 2). Senktide treatment recovered components of ELM (memory for place and object) compared with vehicle-treated animals. After one more week, vehicle or senktide (0.2 mg/kg, s.c.) was applied post-trial and the test conducted 6h later (experiment 3). The senktide-treated group exhibited intact ELM, unlike the vehicle-treated group. Finally, animals received post-trial treatment with either vehicle or SR142801, a selective NK3-R antagonist (6 mg/kg, i.p.), 1 min before senktide injection (0.2 mg/kg, s.c.) in the ELM paradigm and were tested 6h later (experiment 4). The vehicle+senktide group showed intact ELM, while the SR142801+senktide group did not. The results indicate that senktide facilitated the consolidation or the expression of ELM and that the senktide effect was NK3-R dependent.enfalseEpisodic-like memoryNK3 receptorsObject recognitionSenktide[SDGs]SDG3journal article10.1016/j.nlm.2014.06.009249720162-s2.0-84903770837