臺大公衛學院-公共衛生學系;臺大公衛學院-流行病學與預防醫學研究所;Lee, Yungling LeoYungling LeoLeeYUNG-LING LEEHwang, Bing-FangBing-FangHwangHwang, Bing-FangBing-FangHwangChen, Yu-AnYu-AnChenChen, Yu-AnYu-AnChenChen, Jer-MinJer-MinChenWu, Yi-FanYi-FanWuWu, Yi-FanYi-FanWuKreindler, James L.James L.KreindlerKreindler, James L.James L.Kreindler2018-09-102018-09-102012http://www.scopus.com/inward/record.url?eid=2-s2.0-84863369640&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/374859Background: Previous studies revealed that reduction of airway caliber in infancy might increase the risks for wheezing and asthma. However, the evidence for the predictive effects of pulmonary function on respiratory health in children was still inconsistent. Methods: We conducted a population-based prospective cohort study among children in 14 Taiwanese communities. There were 3,160 children completed pulmonary function tests in 2007 and follow-up questionnaire in 2009. Poisson regression models were performed to estimate the effect of pulmonary function on the development of bronchitis and asthma. Results: After adjustment for potential confounders, pulmonary function indices consistently showed protective effects on respiratory diseases in children. The incidence rate ratios of bronchitis and asthma were 0.86 (95% CI 0.79-0.95) and 0.91 (95% CI 0.82-0.99) for forced expiratory volume in 1 second (FEV 1). Similar adverse effects of maximal mid-expiratory flow (MMEF) were also observed on bronchitis (RR = 0.73, 95% CI 0.67-0.81) and asthma (RR = 0.85, 95% CI 0.77-0.93). We found significant decreasing trends in categorized FEV 1 (p for trend = 0.02) and categories of MMEF (p for trend = 0.01) for incident bronchitis. Significant modification effects of traffic-related air pollution were noted for FEV 1 and MMEF on bronchitis and also for MMEF on asthma. Conclusions: Children with high pulmonary function would have lower risks on the development of bronchitis and asthma. The protective effect of high pulmonary function would be modified by traffic-related air pollution exposure. ? 2012 Lee et al.110 bytestext/html[SDGs]SDG3adolescent; air pollution; article; asthma; bronchitis; child; cohort analysis; community care; controlled study; female; forced expiratory volume; forced vital capacity; human; incidence; lung function; lung function test; major clinical study; male; maximal mid expiratory flow; population research; preschool child; prospective study; questionnaire; respiratory tract disease; school child; Taiwan; lung; pathophysiology; Adolescent; Asthma; Bronchitis; Child; Female; Humans; Lung; Male; Prospective Studies; Respiratory Function Tests; Taiwanjournal article10.1371/journal.pone.0032477