Tsai T.-H.Zhou C.HSIANG-CHIEH LEETao Y.K.Ahsen O.O.Figueiredo M.Adler D.C.Schmitt J.M.Huang Q.Fujimoto J.G.Mashimo H.Tsai T.-H.Zhou C.Tao Y.K.Ahsen O.O.Figueiredo M.Adler D.C.Schmitt J.M.Huang Q.Fujimoto J.G.Mashimo H.2020-10-202020-10-202012https://www.scopus.com/inward/record.uri?eid=2-s2.0-84864925030&doi=10.1155%2f2012%2f684832&partnerID=40&md5=81d3ce1831440799cde9766cf4ca8804https://scholars.lib.ntu.edu.tw/handle/123456789/517377Two main nonsurgical endoscopic approaches for ablating dysplastic and early cancer lesions in the esophagus have gained popularity, namely, radiofrequency ablation (RFA) and cryospray ablation (CSA). We report a uniquely suited endoscopic and near-microscopic imaging modality, three-dimensional (3D) optical coherence tomography (OCT), to assess and compare the esophagus immediately after RFA and CSA. The maximum depths of architectural changes were measured and compared between the two treatment groups. RFA was observed to induce 230∼260 m depth of architectural changes after each set of ablations over a particular region, while CSA was observed to induce edema-like spongiform changes to 640 m depth within the ablated field. The ability to obtain micron-scale depth-resolved images of tissue structural changes following different ablation therapies makes 3D-OCT an ideal tool to assess treatment efficacy. Such information could be potentially used to provide real-time feedback for treatment dosing and to identify regions that need further retreatment. Copyright © 2012 Tsung-Han Tsai et al.article; Barrett esophagus; clinical article; comparative study; cryoablation; cryospray ablation; follow up; human; lower esophagus sphincter; optical coherence tomography; radiofrequency ablation; three dimensional imaging; tissue structurejournal article10.1155/2012/6848322-s2.0-84864925030