PO-JEN YANGSer K.-H.MING-TSAN LINNien H.-C.CHIUNG-NIEN CHENWEI-SHIUNG YANGLee W.-J.2020-03-232020-03-2320150960-8923https://www.scopus.com/inward/record.uri?eid=2-s2.0-84947496238&doi=10.1007%2fs11695-015-1688-5&partnerID=40&md5=2f94d0be1804565b3339db3dfc601bb2https://scholars.lib.ntu.edu.tw/handle/123456789/477419Background: Recent studies showed that fetuin-A and matrix metalloproteinase-7 (MMP-7) are type 2 diabetes mellitus (T2DM)-associated markers. Bariatric surgery not only reduces body weight but also improves T2DM. This study aimed to investigate the changes of fetuin-A and MMP-7 in obese subjects with and without T2DM after bariatric surgery. Methods: We enrolled 130 obese subjects that received bariatric surgery, including 41 Roux-en-Y gastric bypass (RYGB), 67 mini-gastric bypass (MGB), and 22 sleeve gastrectomy (SG) patients. Forty-three patients suffered from T2DM prior to surgery. The fasting serum fetuin-A and MMP-7 levels were measured before and 1?year after surgery. Results: Only five of 43 patients remained diabetic after surgery. Preoperative T2DM patients had higher fetuin-A and MMP-7 levels than non-T2DM subjects. RYGB, MGB, and SG all decreased the fetuin-A levels 1?year after the operation. The MMP-7 levels were not changed after RYGB, MGB, or SG. In multivariate analyses, the preoperative fetuin-A was significantly related to the diastolic blood pressure (DBP) and glycosylated hemoglobin (HbA1c), while the postoperative fetuin-A was independently related to the waist-to-hip ratio and HbA1c. Moreover, the preoperative MMP-7 level was significantly related to age, DBP, aspartate transaminase, alanine transaminase, and gamma-glutamyl transferase (rGT), while the postoperative MMP-7 level was independently related to age and rGT. Conclusions: The fetuin-A and MMP-7 levels are both higher in obese T2DM than non-T2DM subjects. The level of fetuin-A is reduced after RYGB, MGB, and SG, but the level of MMP-7 remains unchanged. ? 2015, Springer Science+Business Media New York.[SDGs]SDG3alanine aminotransferase; aspartate aminotransferase; C peptide; fetuin A; gamma glutamyltransferase; glucose; hemoglobin A1c; matrilysin; oral antidiabetic agent; AHSG protein, human; biological marker; fetuin A; glycosylated hemoglobin; matrilysin; MMP7 protein, human; adult; alanine aminotransferase blood level; Article; aspartate aminotransferase blood level; bariatric surgery; diastolic blood pressure; diet therapy; female; gamma glutamyl transferase blood level; glucose blood level; hemoglobin blood level; human; lifestyle modification; major clinical study; male; mini gastric bypass; non insulin dependent diabetes mellitus; obesity; postoperative period; preoperative period; priority journal; protein blood level; sleeve gastrectomy; stomach bypass; waist hip ratio; aged; blood; complication; Diabetes Mellitus, Type 2; diet restriction; down regulation; metabolism; middle aged; obesity; rehabilitation; weight reduction; Adult; Aged; alpha-2-HS-Glycoprotein; Bariatric Surgery; Biomarkers; Diabetes Mellitus, Type 2; Down-Regulation; Fasting; Female; Hemoglobin A, Glycosylated; Humans; Male; Matrix Metalloproteinase 7; Middle Aged; Obesity; Postoperative Period; Waist-Hip Ratio; Weight Lossjournal article10.1007/s11695-015-1688-5259336322-s2.0-84947496238