Wang X.-TZhang Y.-FWang BWang SXing XXu X.-JLiu W.-ZRen N.-QLee D.-JChen C.DUU-JONG LEE2022-03-222022-03-22202209608524https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122501540&doi=10.1016%2fj.biortech.2021.126641&partnerID=40&md5=28eb9335ac7c4eb99d91bc55cafb159bhttps://scholars.lib.ntu.edu.tw/handle/123456789/598178Hybrid microbial electrolysis cells-anaerobic digestion (MEC-AD) was proved to increase methane productivity and methane yield of waste activated sludge (WAS) by establishing direct interspecies electron transfer method and enriching functional microorganisms. This review first summarized the pretreatment methods of WAS for MEC-AD and then reviewed the reactor configurations, operation parameters, and the economic benefit of MEC-AD. Furthermore, the enhancement mechanisms of MEC-AD were reviewed based on the analysis of thermodynamics and microbial community. It was found that the decrease of hydrogen partial pressure due to the hydrogenotrophic methanogens enriched in cathodic biofilm and direct interspecies electron transfer between exoelectrogens and anode were the core mechanisms for improving acidogenesis, acetogenesis, and methanogenesis. Finally, the potentially technological issues that need to be addressed to increase energy efficiency in large-scale MEC-AD processes were discussed. ? 2021 Elsevier LtdAnaerobic digestionEnhancing mechanismMethane productionMicrobial communityMicrobial electrolysis cellWaste activated sludgemethaneanaerobic growthbioreactorelectrolysissewageAnaerobiosisBioreactorsElectrolysisMethaneSewage[SDGs]SDG6[SDGs]SDG7[SDGs]SDG12review10.1016/j.biortech.2021.126641349734052-s2.0-85122501540