Lin C.-L.Chen J.-D.CHUN-JEN LIUPO-HUANG LEEPEI-JER CHENLai M.-Y.JIA-HORNG KAODING-SHINN CHEN2020-11-192020-11-1920071352-0504https://www.scopus.com/inward/record.uri?eid=2-s2.0-33845725647&doi=10.1111%2fj.1365-2893.2006.00776.x&partnerID=40&md5=0e9cb2c7b57948dabe2dc2e380065913https://scholars.lib.ntu.edu.tw/handle/123456789/521417Clinical and pathogenic differences exist between hepatitis B viral (HBV) genotypes B and C, and genotype C has a higher risk of hepatocellular carcinoma (HCC) development than genotype B. The aim of this study was to investigate whether HBV genotypes B and C influence the clinicopathological features of patients with resectable HCC. Stored serum samples from 193 patients with resectable HBV-related HCC were tested for HBV genotypes by a molecular method. Of 193 patients undergoing resection of HCC, 107 (55%) and 86 (45%) were infected with genotypes B and C, respectively. Compared with genotype C patients, genotype B patients were less likely to be associated with liver cirrhosis (33%vs 51%, P = 0.01). Pathologically, genotype B patients had a higher rate of solitary tumour (94%vs 86%, P = 0.048) and more satellite nodules (22%vs 12%, P = 0.05) than genotype C patients. Our results indicate that genotype B-related HCC is less associated with liver cirrhosis and has a higher frequency of solitary tumour as well as more satellite nodules than genotype C-related HCC. These characteristics may contribute to the recurrence patterns and prognosis of HBV-related HCC in patients with genotype B or C infection. ? 2007 The Authors.[SDGs]SDG3adult; article; cancer classification; cancer risk; cancer surgery; controlled study; disease association; female; genotype; Hepatitis B virus; Hepatitis C virus; human; human tissue; liver cell carcinoma; liver cirrhosis; major clinical study; male; pathogenicity; priority journal; prognosis; recurrent disease; solitary fibrous tumor; Alanine Transaminase; alpha-Fetoproteins; Bilirubin; Carcinoma, Hepatocellular; DNA, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Neoplasms; Male; Middle Aged; Polymerase Chain Reaction; Prothrombin Time; Retrospective Studies; Serum Albuminjournal article10.1111/j.1365-2893.2006.00776.x172126462-s2.0-33845725647