KEH-CHUNG LINLi, Yi-ChunYi-ChunLiLin, Yu-FangYu-FangLinLau, Hiu-YingHiu-YingLauKuo, Chih-ChiehChih-ChiehKuoLin, Chia-JungChia-JungLinYI HSUAN WULin, Chih-YuChih-YuLin2025-06-242025-06-242025-05-01https://scholars.lib.ntu.edu.tw/handle/123456789/730229Importance: Stroke rehabilitation in clinic- and home-based settings may yield differential effects on motor and functional outcomes. Objective: To investigate the effects of mirror therapy preceding augmented-reality therapy in the clinic and home setting. Design: Single-blinded, randomized crossover study. Setting: Rehabilitation clinics and home environment of participants. Participants: Thirty-one stroke survivors. Intervention: Participants were randomized to receive clinic-based practice first or home-based practice first. The intervention involved mirror therapy–primed augmented-reality practice. Participants received nine treatment sessions, with a 3-wk washout period between two phases. Outcomes and Measures: Outcome measures included the Fugl-Meyer Assessment Scale of Upper Extremity (FMA–UE), Berg Balance Scale (BBS), Chedoke Arm and Hand Activity Inventory, Motor Activity Log (MAL), and Stroke Impact Scale (SIS). Results: Clinic-based practice significantly improved the FMA–UE (p = .04), BBS (p = .01), and SIS Mobility domain scores (p = .05). Home-based practice showed a trend for better performance on the MAL. Clinic-based practice revealed retention of treatment gains at the 3-mo follow-up assessment on the FMA–UE (p = .01) and the Activities of Daily Living–Instrumental Activities of Daily Living (p = .01), Mobility (p = .02), and Hand Function (p = .03) domains of the SIS. Conclusions and Relevance: Clinic-based practice improved motor and balance deficits, whereas home-based practice may enhance functional arm use. Practice setting is relevant for consideration in stroke rehabilitation. © 2025 American Occupational Therapy Association, Inc. All rights reserved.en[SDGs]SDG3journal article10.5014/ajot.2025.05096140305383