Wang, Hao-JenHao-JenWangMONG-WEI LINChen, Yi-ChangYi-ChangChenChen, Li-WeiLi-WeiChenMIN-SHU HSIEHSHUN-MAO YANGChen, Ho-FengHo-FengChenWang, Chuan-WeiChuan-WeiWangJIN-SHING CHENYEUN-CHUNG CHANGCHUNG-MING CHEN2022-04-152022-04-1520221569-9293https://scholars.lib.ntu.edu.tw/handle/123456789/604563Objectives: Solitary pulmonary capillary haemangioma (SPCH) is a benign lung tumour that presents as ground-glass nodules on computed tomography (CT) images and mimics lepidic-predominant adenocarcinoma. This study aimed to establish a discriminant model using a radiomic feature analysis to distinguish SPCH from lepidic-predominant adenocarcinoma. Methods: In the adenocarcinoma group, all tumours were of the lepidic-predominant subtype with high purity (>70%). A classification model was proposed based on a two-level decision tree and 26 radiomic features extracted from each segmented lesion. For comparison, a baseline model was built with the same 26 features using a support vector machine as the classifier. Both models were assessed by the leave-one-out cross-validation method. Results: This study included 13 and 49 patients who underwent complete resection for SPCH and adenocarcinoma, respectively. Two sets of features were identified for discrimination between the 2 different histology types. The first set included 2 principal components corresponding to the 2 largest eigenvalues for the root node of the two-level decision tree. The second set comprised 4 selected radiomic features. The area under the receiver operating characteristic curve, accuracy, sensitivity, specificity were 0.954, 91.9%, 92.3% and 91.8% in the proposed classification model, and were 0.805, 85.5%, 61.5% and 91.8% in the baseline model, respectively. The proposed classification model significantly outperformed the baseline model (P < 0.05). Conclusions: The proposed model could differentiate the 2 different histology types on CT images, and this may help surgeons to preoperatively discriminate SPCH from adenocarcinoma.enComputed tomographyGround-glass noduleLung adenocarcinomaLung cancer surgerySolitary pulmonary capillary haemangioma[SDGs]SDG3[SDGs]SDG10journal article10.1093/icvts/ivab271346486312-s2.0-85123118304WOS:000759084100005https://api.elsevier.com/content/abstract/scopus_id/85123118304