外科CHEN, CHIUNG-NIENCHIUNG-NIENCHEN2009-01-082018-07-112009-01-082018-07-112002http://ntur.lib.ntu.edu.tw//handle/246246/96275Background: The definitive operation for chronic ulcerative colitis (UC) and familial adenomatous polyposis is total proctocolectomy with ileal pouch-anal anastomosis (TPAA). : Mild inflammation (pouchitis) is omnipresent in pouches and becomes severe in 50% of UC patients with IPAA. The etiology of pouchitis is likely due to combined genetic, microbial, and immunologic factors. Epithelial cell exposure to surgical trauma and/ or to changes in intestinal bacterial composition may account for the inflammatory infiltrate. Progress in understanding pouchitis is restricted by the lack of suitable animal models. Methods: An ileal pouch- rectal anastomosis [IPRA] in rats was developed to reproduce a model of human IPAA and clinical, gross and histologic criteria were determined. Results: Many shared features with human ileal pouch were observed. Conclusion: IPRA is an important in vivo model to study mechanisms of repair, defense and immunity that may contribute to pouchitis. (C) 2002 Excerpts Medica, Inc. All rights reserved.en-USileal pouch rectal anastomosispouchitispeyer's patchesULCERATIVE-COLITISRESTORATIVE PROCTOCOLECTOMYANAL ANASTOMOSISjournal article