2011-08-012024-05-18https://scholars.lib.ntu.edu.tw/handle/123456789/697903摘要：山藥(Dioscorea opposita)在許多亞洲國家當作滋養強壯藥和食材已經有數個世紀之久，傳統中醫藥典籍記載山藥為對健康具有許多助益之上品藥材，例如止瀉痢。此外，山藥也有滋補功效，可恢復或促進免疫和消化系統之功能。山藥所含成分中，雖然有許多具有營養價值，但難以解釋其生物活性。文獻報告指出山藥皂&#33527;元主成分diosgenin具有許多藥理作用，例如計畫申請人先前研究成果指出山藥皂&#33527;元對卵白蛋白免疫小鼠，對於其抗原專一性抗體IgG2a的生成和細胞激素干擾素(interferon)-γ的表現，具有顯著的促進作用，顯示對第一型輔助T細胞(Th1)免疫反應的促進效果。基於這些發現，以及計畫申請人初步成果顯示山藥皂&#33527;元於食物過敏小鼠模式中，具有抑制其過敏原誘發的發炎反應和腸道的組織受損之抗過敏活性，本三年期研究計畫擬深入探討山藥皂&#33527;元抗食物過敏作用之免疫機轉。<br> Abstract: Chinese yam (shan yao; Dioscorea opposite) has been used in several Asian countries for many centuries as a herbal medicine, as well as a food supplement. The literature of traditional Chinese medicine indicates that Chinese yam is a superior herb with a number of therapeutic effects, such as anti-diarrhea. In addition, Chinese yam is utilized as a tonic herb to restore and enhance the function of the immune and gastrointestinal system. Chinese yam contains a variety of nutrients that are generally believed to be of nutritional value, but are unlikely responsible for its biological activities. Previous studies have demonstrated that diosgenin, the major steroidal sapogenin contained in Chinese yam, exhibited a number of pharmacological effects. For example, the applicant has recently reported that diosgenin administration enhanced antigen-specific IgG2a and interferon (IFN)-γ expression in ovalbumin-sensitized mice, suggesting an enhancing effect on T helper (Th)1 cell-mediated immunity. Based on these findings and the applicant’s preliminary results showing the attenuation of allergen-induced inflammatory responses and tissue damage in the gut, the proposed 3-year project aims to investigate the immunological mechanisms responsible for the anti-allergic effect of diosgenin against food allergy.山藥山藥皂&#33527元食物過敏免疫小鼠Chinese yamdiosgeninfood allergyimmunemice