Liu Y.-W.Cheng Y.-B.Liaw C.-C.Chen C.-H.JIH-HWA GUHHwang T.-L.Tsai J.-S.WON-BO WANGShen Y.-C.2019-09-022019-09-0220120163-3864https://www.scopus.com/inward/record.uri?eid=2-s2.0-84860340216&doi=10.1021%2fnp200932k&partnerID=40&md5=05106cd7aa6605c1530ec944f8b7dc80https://scholars.lib.ntu.edu.tw/handle/123456789/417091Investigation of the leaves and twigs of Callicarpa longissima resulted in the isolation of four new compounds (1-4), callilongisins A-D, and five known compounds, ursolic acid, 3-oxoanticopalic acid, (E)-6β-hydroxylabda-8(17), 13-dien-15-oic acid, 5-hydroxy-3,6,7,4′-tetramethoxyflavone, and artemetin. Compounds 1-3 are 3,4-seco-abietane-type diterpenoids, and compound 4 is an analogue of a labdenoic-type diterpene. The structure of compound 1 was confirmed by X-ray crystallographic analysis. Cytotoxicity against a human prostate cancer cell line (PC3) and anti-inflammatory activities of the isolated compounds were evaluated. ? 2012 The American Chemical Society and American Society of Pharmacognosy.en-US[SDGs]SDG313 dien 15 oic acid; 3 oxoanticopalic acid; 3,4 seco abietane; 5 hydroxy 3,6,7,4 tetramethoxyflavone; 6beta hydroxylabda 8; artemetin; Callicarpa longissima extract; callilongisin A; callilongisin B; callilongisin C; callilongisin D; diterpene; plant extract; unclassified drug; ursolic acid; antiinflammatory activity; article; Callicarpa longissima; cancer cell culture; cytotoxicity; drug activity; drug isolation; drug structure; human; human cell; medicinal plant; nonhuman; prostate cancer; X ray crystallography; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Callicarpa; Crystallography, X-Ray; Diterpenes; Drug Screening Assays, Antitumor; Humans; Male; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant LeavesBioactive diterpenes from Callicarpa longissimajournal article10.1021/np200932k224290522-s2.0-84860340216