Li C.Y.YIH-LEONG CHANGChen W.C.Lee Y.C.2020-03-072020-03-0720100929-6646https://www.scopus.com/inward/record.uri?eid=2-s2.0-77955873318&doi=10.1016%2fS0929-6646%2810%2960069-1&partnerID=40&md5=83dfa1d806889125e485abd7ea2b96f5https://scholars.lib.ntu.edu.tw/handle/123456789/473843Proteus syndrome is a very rare, sporadic and congenital condition that is characterized by postnatal mosaic overgrowth. This disorder is thought to be caused by a somatic gene mutation, but the exact etiology is unknown. Commonly involved tissues include connective tissue, bone, skin and the central nervous system. Another less common symptom involves pulmonary emphysematous changes. This report documents a 25-year-old man with Proteus syndrome who presented with progressive exertional dyspnea and asymmetric overgrowth of his extremities. He underwent left pneumonectomy and his postoperative course was uneventful. Lung tissue showed emphysematous changes with multiple bulla formation and scattered calcification. We also review recent literature related to pulmonary manifestations and management of Proteus syndrome. ? 2010 Elsevier & Formosan Medical Association.[SDGs]SDG3C reactive protein; adult; article; atelectasis; blister; calcification; case report; computer assisted tomography; dyspnea; finger amputation; finger malformation; forced expiratory volume; forced vital capacity; human; human tissue; leg varicosis; lung emphysema; lung parenchyma; lung perfusion; lung resection; male; multiple cancer; radioactivity; spirometry; thorax radiography; vesicular rash; genetics; lung; lung emphysema; multiple cancer; pathology; radiography; treatment outcome; Adult; Humans; Lung; Male; Proteus Syndrome; Pulmonary Emphysema; Tomography, X-Ray Computed; Treatment Outcomejournal article10.1016/S0929-6646(10)60069-1204978742-s2.0-77955873318