2021-08-012024-05-18https://scholars.lib.ntu.edu.tw/handle/123456789/698983細菌RNA已知有較強的抗原性，然而細菌RNA或核醣體蛋白對免疫系統之關係未明。我們證實了共生鏈球菌核醣體蛋白為SLE潛在致病性抗體。此抗體相較於對照 組，特異性可高達93%。我們將探討此蛋白誘發SLE抗體生成的機轉，並以SLE兩種動物模式，探討此蛋白對SLE之影響。此成果可用於新藥開發及生物標記研發。systemic lupus erythematosuscommensal bacteriaribosomal proteinautoantibodylupus nephritisrituximabbiologicsClinical Relevance and Immunopathogenesis of Serum Antibody against Ribosomal Protein Derived from Commensal Bacteria in Systemic Lupus Erythematosus(2nd-4th Year)