Heckman M.G.Soto-Ortolaza A.I.Aasly J.O.Abahuni N.Annesi G.Bacon J.A.Bardien S.Bozi M.Brice A.Brighina L.Carr J.Chartier-Harlin M.-C.Dardiotis E.Dickson D.W.Diehl N.N.Elbaz A.Ferrarese C.Fiske B.Gibson J.M.Gibson R.Hadjigeorgiou G.M.Hattori N.Ioannidis J.P.A.Boczarska-Jedynak M.Jasinska-Myga B.Jeon B.S.Kim Y.J.Klein C.Kruger R.Kyratzi E.Lesage S.CHIN-HSIEN LINLynch T.Maraganore D.M.Mellick G.D.Mutez E.Nilsson C.Opala G.Park S.S.Petrucci S.Puschmann A.Quattrone A.Sharma M.Silburn P.A.Sohn Y.H.Stefanis L.Tadic V.Theuns J.Tomiyama H.Uitti R.J.Valente E.M.Van Broeckhoven C.Van De Loo S.Vassilatis D.K.Vilariño-Güell C.White L.R.Wirdefeldt K.Wszolek Z.K.RUEY-MEEI WUHentati F.Farrer M.J.Ross O.A.2020-11-032020-11-0320130885-3185https://www.scopus.com/inward/record.uri?eid=2-s2.0-84886446293&doi=10.1002%2fmds.25600&partnerID=40&md5=6f339f102808c1714878b06ea95afa6chttps://scholars.lib.ntu.edu.tw/handle/123456789/520067Background: Variants within the leucine-rich repeat kinase 2 gene are recognized as the most frequent genetic cause of Parkinson's disease. Leucine-rich repeat kinase 2 variation related to disease susceptibility displays many features that reflect the nature of complex, late-onset sporadic disorders like Parkinson's disease. Methods: The Genetic Epidemiology of Parkinson's Disease Consortium recently performed the largest genetic association study for variants in the leucine-rich repeat kinase 2 gene across 23 different sites in 15 countries. Results: Herein, we detail the allele frequencies for the novel risk factors (p.A419V and p.M1646T) and the protective haplotype (p.N551K-R1398H-K1423K) nominated in the original publication. Simple population allele frequencies not only can provide insight into the clinical relevance of specific variants but also can help genetically define patient groups. Conclusions: Establishing individual patient-based genomic susceptibility profiles that incorporate both risk factors and protective factors will determine future diagnostic and treatment strategies. ? 2013 Movement Disorder Society.[SDGs]SDG3leucine rich repeat kinase 2; allele; Alzheimer disease; article; disease predisposition; dyskinesia; gene frequency; genetic epidemiology; genetic risk; genetic screening; genetic susceptibility; genetic variability; human; impulse control disorder; Parkinson disease; priority journal; risk factor; association study; genetics; LRRK2; Parkinson's disease; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genetics, Population; Genotype; Haplotypes; Humans; Molecular Epidemiology; Parkinson Disease; Polymorphism, Single Nucleotide; Protein-Serine-Threonine Kinasesjournal article10.1002/mds.25600239137562-s2.0-84886446293