HUI-HSIN KOPeng H.-H.SHIH-JUNG CHENGYEN-PING KUO2021-07-052021-07-0520181043-3074https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056484256&doi=10.1002%2fhed.25370&partnerID=40&md5=14a08135c36adfea6190cb749c511afdhttps://scholars.lib.ntu.edu.tw/handle/123456789/569126Background: Aldo-keto reductase family 1 member B10 (AKR1B10) expression in oral squamous cell carcinoma (OSCC) tissue specimens is correlated with the progression and prognosis of OSCC. Methods: Saliva samples were obtained from 35 normal controls and 86 patients with OSCC before cancer surgery. The AKR1B10 levels were determined using enzyme-linked immunosorbent assay (ELISA). Results: The mean salivary AKR1B10 levels were significantly higher in the patients with OSCC than in the normal controls (P <.001). Higher salivary AKR1B10 levels were significantly associated with larger tumor size, more advanced clinical stage, and areca quid chewing habit. Patients with OSCC with a higher salivary AKR1B10 level (>646 pg/mL) had a significantly poorer survival than those with a lower (?646 pg/mL) salivary AKR1B10 level (P =.026). Conclusion: The salivary AKR1B10 level may be a promising biomarker for screening high-risk patients with OSCC and monitoring the progression of OSCC. ? 2018 Wiley Periodicals, Inc.[SDGs]SDG3aldo keto reductase family 1 member B10; biological marker; AKR1B10 protein, human; aldo keto reductase; tumor marker; adult; areca quid; Article; cancer growth; cancer prognosis; cancer staging; cancer surgery; controlled study; eating habit; enzyme linked immunospot assay; female; human; major clinical study; male; mastication; middle aged; mouth squamous cell carcinoma; priority journal; protein expression; saliva analysis; salivation; survival; tumor volume; chemistry; disease exacerbation; early cancer diagnosis; Kaplan Meier method; mortality; mouth tumor; pathology; procedures; prognosis; saliva; squamous cell carcinoma; Adult; Aldo-Keto Reductases; Biomarkers, Tumor; Carcinoma, Squamous Cell; Disease Progression; Early Detection of Cancer; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Mouth Neoplasms; Prognosis; Salivajournal article10.1002/hed.25370304306722-s2.0-85056484256