Yang W.-S.Chen Y.-Y.Chen P.-C.Hsu H.-C.TA-CHEN SUHUNG-JU LINMING-FONG CHENLee Y.-T.KUO-LIONG CHIEN2020-09-282020-09-2820192045-2322https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076552395&doi=10.1038%2fs41598-019-55686-7&partnerID=40&md5=42874d5131adcae1683407efbb34918chttps://scholars.lib.ntu.edu.tw/handle/123456789/514731Most studies support that saturated fatty acid replacement with polyunsaturated fatty acids (PUFAs) may reduce the risk of cardiovascular diseases (CVDs) and put emphasis on the effects of N-3 PUFAs. The reported relationships between N-6 PUFAs and CVD risks vary. We aimed to examine the associations between N-6 PUFA concentrations and CVD risks. In this community-based prospective cohort study on CVD-free patients at baseline (N = 1835, age: 60.6 ± 10.5 years, women: 44.5%), we measured the fatty acid concentrations in the blood using gas chromatography. Four hundred twenty-four participants developed CVDs during follow up. The total N-6 PUFA concentration was inversely associated with the CVD risk, with a 48% lower risk in the highest N-6 PUFA concentration quartile (hazard ratio = 0.52; P for trend <0.001). The estimated population attributable risk of N-6 PUFAs indicated that approximately 20.7% of CVD events would have been prevented if the plasma N-6 PUFA concentration had been higher than the median value. The total N-6 PUFA concentration presented the highest net reclassification improvement (NRI = 7.2%, P = 0.03) for predicting incident CVD. Further studies on N-6 PUFAs, diet habits, and their relationships with healthcare are warranted. ? 2019, The Author(s).[SDGs]SDG3omega 6 fatty acid; unsaturated fatty acid; aged; blood; cardiovascular disease; fat intake; feeding behavior; female; follow up; gas chromatography; genetic predisposition; health care delivery; human; male; middle aged; pathology; risk factor; Aged; Cardiovascular Diseases; Chromatography, Gas; Delivery of Health Care; Dietary Fats; Fatty Acids, Omega-6; Fatty Acids, Unsaturated; Feeding Behavior; Female; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Risk Factorsjournal article10.1038/s41598-019-55686-7318484132-s2.0-85076552395