JUN-CHAU CHIENBaker, Sam W.Sam W.BakerGates, KatherineKatherineGatesSeo, Ji WonJi WonSeoArbabian, AminAminArbabianSoh, H. TomH. TomSoh2023-07-172023-07-172022-01-019781665469173https://scholars.lib.ntu.edu.tw/handle/123456789/633782This paper presents a wireless electrochemical sensing system for in vivo small-molecule sensing with structure-switching aptamers. A 65-nm CMOS electrochemical sensing circuit with an on-chip waveform generator is integrated with a Bluetooth microcontroller and battery for robust wireless recording. The device performs data acquisition every 10 seconds and consume an average current of 3mA after duty-cycling. Real-time sensing of infused antibiotics (kanamycin) concentration in the interstitial fluids (ISF) are demonstrated on a freely-moving animal.aptamers | Bluetooth | CMOS | electrochemical | freely-moving | in vivo | power management | wireless[SDGs]SDG7conference paper10.1109/BioCAS54905.2022.99485862-s2.0-85142936292https://api.elsevier.com/content/abstract/scopus_id/85142936292