Chao, C.-H.C.-H.ChaoWu, C.-Y.C.-Y.WuHuang, C.-Y.C.-Y.HuangWang, H.-C.H.-C.WangCHANG-FENG DAIWu, Y.-C.Y.-C.WuSheu, J.-H.J.-H.Sheu2018-09-102018-09-102016http://www.scopus.com/inward/record.url?eid=2-s2.0-84984924449&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/396844Two new cubitanoids, nanoculones A and B (1 and 2), and three new cembranoids, nanolobols A-C (3-5), as well as six known compounds, calyculone I (6), sinulariuol A (7), sinulariols C, D, H, and J (8-11), were isolated from the soft coral Sinularia nanolobata, collected off the coast of the eastern region of Taiwan. Their structures were elucidated on the basis of extensive spectroscopic analysis. Cytotoxicity of compounds 1-11 was evaluated. The nitric oxide (NO) inhibitory activity of selected compounds was further measured by assay of lipopolysaccharide (LPS)-stimulated NO production in activated RAW264.7 cells. The results showed that none of 1-11 exhibited cytotoxicity against the tested cancer cell lines, whereas compound 8 was found to significantly reduce NO production. ? 2016 by the authors; licensee MDPI.Cubitane; Nanoculones A and B; Nanolobols A-C; Sinularia[SDGs]SDG3calyculone I; cembranoid; cubitanoid derivative; diterpenoid; lipopolysaccharide; nanoculone A; nanoculone B; nanolobol A; nanolobol B; nanolobol C; nitric oxide; sinulariol C; sinulariol D; sinulariol H; sinulariol J; sinulariuol A; unclassified drug; antineoplastic agent; diterpene; nitric oxide; animal cell; Article; cancer cell line; carbon nuclear magnetic resonance; colon adenocarcinoma; controlled study; coral; drug cytotoxicity; drug isolation; drug structure; human; human cell; leukemia; mass spectrometry; nonhuman; proton nuclear magnetic resonance; Sinularia nanolobata; structure analysis; Taiwan; animal; Anthozoa; chemical structure; chemistry; drug screening; HT-29 cell line; isolation and purification; K-562 cell line; metabolism; mouse; RAW 264.7 cell line; Animals; Anthozoa; Antineoplastic Agents; Diterpenes; Drug Screening Assays, Antitumor; HT29 Cells; Humans; K562 Cells; Lipopolysaccharides; Mice; Molecular Structure; Nitric Oxide; RAW 264.7 Cellsjournal article10.3390/md140801502-s2.0-84984924449WOS:000383284700002