Chang, C.-M.C.-M.ChangYI-HO YOUNGJaw, F.-S.F.-S.JawWang, C.-T.C.-T.WangCheng, P.-W.P.-W.ChengFU-SHAN JAW2020-02-262020-02-262017https://scholars.lib.ntu.edu.tw/handle/123456789/464110Objective The staging system of Meniere's disease utilizes audiograms to probe cochlear dysfunction. We explored the addition of galvanic vestibular-evoked myogenic potentials (VEMP) to further explore vestibular function. Methods Seventy patients with unilateral Meniere's disease were enrolled in this study. Within 2?weeks of diagnosis, all subjects underwent pure tone audiometry, cervical and ocular VEMP, and caloric test. The prevalence of abnormal tests and the VEMP characteristic parameters such as latencies and amplitudes were analyzed. Results In affected ears, the abnormal rate of acoustic cVEMPs, galvanic cVEMPs, vibratory oVEMPs and galvanic oVEMPs was 37%, 17%, 20%, and 9%, respectively. No significant differences existed in VEMP latencies and amplitudes between affected ears and unaffected ears. Conclusions The impairment of otolithic organs was found to be more than that of vestibular afferents. The deterioration of the saccule was more than that of the utricle, whereas retrolabyrinthine degeneration of sacculo-collic reflex and vestibulo-ocular reflex was similar. Significance This study is the first to use an electrophysiological test to evaluate the retrolabyrinthine function of patients with unilateral Meniere's disease. ? 2017 International Federation of Clinical NeurophysiologyCervical vestibular-evoked myogenic potential; Galvanic vestibular stimulation; Meniere's disease; Ocular vestibular-evoked myogenic potential[SDGs]SDG3adult; aged; Article; brain stem; caloric vestibular test; cervical vestibular evoked myogenic potential; female; galvanic vestibular test; human; inner ear; latent period; major clinical study; male; Meniere disease; nerve degeneration; ocular vestibular evoked myogenic potential; prevalence; priority journal; pure tone audiometry; vestibular evoked myogenic potential; vestibular function; vestibular nerve; audiometry; electrodermal response; electromyography; Meniere disease; middle aged; nerve degeneration; pathophysiology; physiology; procedures; prospective study; vestibular evoked myogenic potential; vestibular nerve; young adult; Adult; Aged; Audiometry; Electromyography; Female; Galvanic Skin Response; Humans; Male; Meniere Disease; Middle Aged; Nerve Degeneration; Prospective Studies; Vestibular Evoked Myogenic Potentials; Vestibular Nerve; Young Adultjournal article10.1016/j.clinph.2017.06.0042-s2.0-85024096082https://www.scopus.com/inward/record.uri?eid=2-s2.0-85024096082&doi=10.1016%2fj.clinph.2017.06.004&partnerID=40&md5=c67b871e401956f3f78f8eb24fed1a46