Yang, Shu-JyuanShu-JyuanYangTseng, Shu-YiShu-YiTsengWang, Chung-HaoChung-HaoWangYoung, Tai-HorngTai-HorngYoungKE-CHENG CHENMING-JIUM SHIEH2021-08-052021-08-05202017435889https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096202702&doi=10.2217%2fnnm-2020-0222&partnerID=40&md5=f58b0cc75793b05e94db4771853ae691https://scholars.lib.ntu.edu.tw/handle/123456789/577245Aim: Cells with CD133 overexpression, a theoretical cancer stem cells (CSCs) marker, have been shown to induce colorectal cancer (CRC) initiation and relapse. Therefore, the detection and treatment of CSCs are the most important factors in overcoming CRC. Materials & methods: Herein, we developed a magnetite-based nanomedicine (superparamagnetic iron oxide@poly(sodium styrene sulfonate)/irinotecan/human serum albumin-anti-CD133 nanoparticle) using loco-regional hyperthermia combined with chemotherapy for CRC- and CSC-specific targeting treatment. Results: The designed nanoparticles were highly biocompatible and exhibited a higher temperature increase rate under radiofrequency generator irradiation. The nanoparticles could be used as a T2-weighted magnetic resonance imaging contrast media, and also applied during hyperthermia and chemotherapy to display a synergistic anticancer effect. Conclusion: Therefore, the superparamagnetic iron oxide@poly(sodium styrene sulfonate)/irinotecan/human serum albumin-anti-CD133 nanoparticles are a powerful candidate for future antitumor strategies. ? 2020 Future Medicine Ltd.. All rights reserved.enCD133 antigen; irinotecan; magnetite nanoparticle; nuclear magnetic resonance imaging agent; polystyrenesulfonate sodium; serum albumin; superparamagnetic iron oxide nanoparticle; animal experiment; animal model; animal tissue; antineoplastic activity; Article; cancer chemotherapy; cancer stem cell; colon cancer; colorectal cancer; controlled study; drug delivery system; female; high temperature procedures; human; molecularly targeted therapy; mouse; nonhuman; nuclear magnetic resonance imaging; priority journal; protein expression; radiofrequency radiation; thermotherapy[SDGs]SDG3CD133 antigen; irinotecan; magnetite nanoparticle; nuclear magnetic resonance imaging agent; polystyrenesulfonate sodium; serum albumin; superparamagnetic iron oxide nanoparticle; magnetite nanoparticle; animal experiment; animal model; animal tissue; antineoplastic activity; Article; cancer chemotherapy; cancer stem cell; colon cancer; colorectal cancer; controlled study; drug delivery system; female; high temperature procedures; human; molecularly targeted therapy; mouse; nonhuman; nuclear magnetic resonance imaging; priority journal; protein expression; radiofrequency radiation; thermotherapy; hyperthermia; magnetism; nanomedicine; neoplasm; tumor cell line; Cell Line, Tumor; Humans; Hyperthermia; Hyperthermia, Induced; Magnetic Resonance Imaging; Magnetics; Magnetite Nanoparticles; Nanomedicine; Neoplasmsjournal article10.2217/nnm-2020-0222331039612-s2.0-85096202702