Spontaneous resolution of acute gouty arthritis is associated with rapid induction of the anti-inflammatory factors TGFβ1, IL-10 and soluble TNF receptors and the intracellular cytokine negative regulators CIS and SOCS3

Chen, Yu-HsuanYu-HsuanChenSONG-CHOU HSIEHChen, Wei-YuWei-YuChenKO-JEN LICHENG-HAN WUWu, Po-ChangPo-ChangWuTsai, Chang-YouhChang-YouhTsaiCHIA-LI YU2022-02-102022-02-102011-090003-4967https://scholars.lib.ntu.edu.tw/handle/123456789/593992The molecular basis for spontaneous resolution of acute gouty arthritis (GA) remains unclear. The hypothesis that extracellular and intracellular mechanisms play roles in resolving acute GA was tested.enTUMOR-NECROSIS-FACTOR; MONOSODIUM URATE CRYSTALS; INDUCED ACUTE-INFLAMMATION; MONOHYDRATE CRYSTALS; IMMUNE-RESPONSES; GENE-EXPRESSION; SYNOVIAL-FLUID; IN-VITRO; MACROPHAGES; CRITERIA[SDGs]SDG3[SDGs]SDG5cytokine inducible SH2 containing protein; interleukin 1 receptor blocking agent; interleukin 10; messenger RNA; regulator protein; small interfering RNA; suppressor of cytokine signaling; suppressor of cytokine signaling 1; suppressor of cytokine signaling 2; suppressor of cytokine signaling 3; suppressor of cytokine signaling 4; suppressor of cytokine signaling 5; suppressor of cytokine signaling 6; suppressor of cytokine signaling 7; transforming growth factor beta1; tumor necrosis factor receptor 1; tumor necrosis factor receptor 2; unclassified drug; urate; acute disease; animal cell; article; cell stimulation; clinical article; controlled study; cytokine production; enzyme linked immunosorbent assay; gene silencing; gout; human; human cell; human tissue; immunoblotting; immunohistochemistry; macrophage; mononuclear cell; mouse; nonhuman; osteoarthritis; priority journal; promoter region; protein analysis; protein binding; protein expression; quantitative assay; reverse transcription polymerase chain reaction; synovial fluid level; synovium; upregulation; Acute Disease; Animals; Arthritis, Gouty; Cells, Cultured; Cytokines; Humans; Inflammation Mediators; Interleukin-10; Macrophages; Mice; Osteoarthritis, Knee; Receptors, Tumor Necrosis Factor; Remission, Spontaneous; Suppressor of Cytokine Signaling Proteins; Synovial Fluid; Synovial Membrane; Transforming Growth Factor beta1; Uric AcidSpontaneous resolution of acute gouty arthritis is associated with rapid induction of the anti-inflammatory factors TGFβ1, IL-10 and soluble TNF receptors and the intracellular cytokine negative regulators CIS and SOCS3journal article10.1136/ard.2010.145821216133122-s2.0-80955177526WOS:000293275600024https://scholars.lib.ntu.edu.tw/handle/123456789/540835