流行病學研究所;Graduate Institute of EpidemiologyCHENG, YU-JUENYU-JUENCHENGHSU, MOW-MINGMOW-MINGHSU2008-09-302018-06-292008-09-302018-06-292003http://ntur.lib.ntu.edu.tw//handle/246246/82031NPC2 is rare in most populations around the world but common in southern China and Southeast Asia. Both genetic and environmental factors are purported to account for the development of NPC. Many Phase I and Phase II enzymes get involved in the metabolism of carcinogens. Some of these enzymes are polymorphic in genotypes that show considerable variation in their activities, which, in turn, determine individual susceptibility to cancer risk (1) . No studies to date have examined simultaneously the association between genetic polymorphisms of multiple xenobiotic-metabolizing enzymes and NPC. We have previously reported an association between genetic polymorphism in the CYP2E1 gene and risk of NPC (2) . In this study, we examine the association with NPC of genetic polymorphisms of CYP1A1, GSTM1, GSTT1, GSTP1, and NAT2.en-USCANCERRISKIDENTIFICATIONSUSCEPTIBILITYBLADDERCYP2E1[SDGs]SDG3journal article