The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase

Yang, Yi-ChiehYi-ChiehYangLin, Yung-WeiYung-WeiLinLee, Wei-JiunnWei-JiunnLeeLai, Feng-RuFeng-RuLaiHo, Kuo-HaoKuo-HaoHoChu, Chih-YingChih-YingChuKUO-TAI HUAChen, Ji-QingJi-QingChenTung, Min-CheMin-CheTungHsiao, MichaelMichaelHsiaoWen, Yu-ChingYu-ChingWenChien, Ming-HsienMing-HsienChien2024-03-262024-03-262023-08-1410217770https://scholars.lib.ntu.edu.tw/handle/123456789/641377KH-type splicing regulatory protein (KHSRP, also called KSRP), a versatile RNA-binding protein, plays a critical role in various physiological and pathological conditions through modulating gene expressions at multiple levels. However, the role of KSRP in clear cell renal cell carcinoma (ccRCC) remains poorly understood.enEMT; KSRP; NEDD4L; Progression; ccRCC[SDGs]SDG3The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligasejournal article10.1186/s12929-023-00949-9375807572-s2.0-85168201039https://api.elsevier.com/content/abstract/scopus_id/85168201039