Chiou, Wei-ChungWei-ChungChiouLu, Hsu-FengHsu-FengLuChen, Jui-ChiehJui-ChiehChenLai, Yu-HengYu-HengLaiMING-FU CHANGHuang, Yuan-LiYuan-LiHuangTien, NiNiTienHuang, ChengChengHuang2023-02-082023-02-082022-10-171743-422Xhttps://scholars.lib.ntu.edu.tw/handle/123456789/627760Hepatitis delta virus (HDV), a satellite virus of hepatitis B virus (HBV), is a small, defective RNA virus strongly associated with the most severe form of hepatitis and progressive chronic liver disease and cirrhosis. Chronic hepatitis D, resulting from HBV/HDV coinfection, is considered to be the most severe form of viral hepatitis and affects 12-20 million people worldwide. Involved in the endocytosis and exocytosis of cellular and viral proteins, clathrin contributes to the pathogenesis and morphogenesis of HDV. Previously, we demonstrated that HDV-I and -II large hepatitis delta antigens (HDAg-L) possess a putative clathrin box that interacts with clathrin heavy chain (CHC) and supports HDV assembly.enClathrin box; Clathrin heavy chain; HDV genotypes; Hepatitis delta antigen; W box[SDGs]SDG3journal article10.1186/s12985-022-01866-3362538592-s2.0-85139930218WOS:000869244900001https://api.elsevier.com/content/abstract/scopus_id/85139930218