2019-08-012024-05-13https://scholars.lib.ntu.edu.tw/handle/123456789/654031摘要：本計畫利用4-isocyanato-4′-(3,3-dimethyl-2,4-dioxoazetidino)diphenylmethane (IDD) 的反應選擇性合成出一系列兩性型高分子材料，包括非離子型(nonionic surfactants)、陽離子型(cationic surfactants)、陰離子型(anionic surfactants)與多親水基型(Germini surfactants)的界面活性劑，探討材料結構特性與光譜鑑定的準確性之研究(第一年)。界面活性劑所呈現出來的膠體與界面現象；包括臨界微胞濃度(critical micelle concentration, CMC)、臨界微胞表面張力(γCMC)、克拉夫特點(Krafft point)、親疏水平衡值(hydrophile-lipophile babance, HLB)與最低臨界相轉移溫度(lower critical solution temperature, LCST)等界面活性劑性質與物理現象量測之研究(第二年)。透過兩性型高分子上的化學結構，在經過高濕度環境下的breath figure將自組裝出孔洞，調控蜂窩狀影響孔洞的品質、尺寸與形態，將自組裝排列之奈米微結構將作為分子模板以利於應用。無機物分散劑(surfactant-stabilized inorganic materials)將透過離子交換，將水相的無機物如氧化石墨(graphene oxide)與二硫化鉬(MoS2)分散至有機相，穩定無機物在溶液態的分散性；同時構築單元上含有豐富的電子對羰基(-C=O)，將成為無機物成核點(nucleation sites)，控制無機物均勻成長；而構築單元上的豐富氫鍵，將依結構與官能基的不同，展現出最低臨界相轉移行為(LCST)的溫感材料，經過能控制的金屬粒子間距與孔洞大小，將優化表面增強拉曼現象(surface-enhanced Raman scattering, SERS)，最適化待測物在拉曼增強效應的最佳條件，利用溫敏材料在不同溫度下提升訊號強度與靈敏度(第三年)。<br> Abstract: A building block, 4-isocyanato-4’(3,3-dimethyl-2,4-dioxo-azetidino) diphenylmethane (IDD), featuring dual functional groups, has a highly reactive isocyanate functional group, and a selectively reactive azetidine-2,4–dione functional group. Higher generation amphiphilic dendrons as surfactants will be obtained by the addition reaction with another building block diethyltriamine (DETA), including nonionic surfactants, cationic surfactants, anionic surfactants and germini surfactants (FIRST YEAR). Critical micelle concentration (CMC), surface tension at CMC, Krafft point, hydrophile-lipophile balance (HLB) and lower critical solution temperature (LCST) of amphiphilic dendrons as surfactants will be studied (SECOND YEAR). Dendrons with various peripheral moieties exhibit unique hydrophilicity when they undergo a self-assembly process. We will investigate structural characteristics and self-assembly behavior using breath figure method. Graphene oxide and molybdenum disulfide (MoS2) will be dispered in organic phase via ion exchange with surfactant-stabilized inorganic materials to improve solubility. As a result, the nanoparticles will nucleate on carbonyl groups (-C=O) of the amphiphilic dendrimers, particularly malonamide linkage segments. The dendritic and linear malonamide linkages extend into water phase that complex with ionic species. This would provide the effective suspension and steric stabilization to efficiently prevent nanoparticles from collision and flocculation. The unique structure of dendritic polymers will be utilized as the templates, and subsequently chemical reduction is performed to generate a new type of organic/metallic nanohybrids with the feature of nanoparticle array. These dendritic polymer/nanoparticle hybrids (e.g. silver nanoparticle array) are applicable for using as Raman-enhancing substrates in biomedical fields (THIRD YEAR).表面增強拉曼規則樹枝狀高分子界面活性劑Breath figure自組裝奈米微粒SERSdendronssurfactantbreath figureself-assemblynanoparticles