陳保中2006-07-252018-06-292006-07-252018-06-292002-07-31http://ntur.lib.ntu.edu.tw//handle/246246/4954雖然國內氯乙烯聚合工人世代曾發表過肝功 能異常、肝硬化或肝癌、及基因傷害相關的論文， 但並不曾探討氯乙烯單體對生殖系統及下一代的 影響；男性氯乙烯單體暴露工人曾被報導會導致性 慾下降及影響精子生成，但對於是否會影響下一代 健康並無一致的結論；因此值得近一步探討男性氯 乙烯聚合工人世代的生育能力及對下一代出生異 常的影響。本研究分為受孕所需時間及異常出生結 果兩部份，懷孕所需時間研究部份為一回溯性世代 研究，主要探討男性氯乙烯聚合工人配偶受孕所需 時間及異常懷孕狀況如自然流產及死產等，連結台 灣結婚登記資料庫共有416 位男性氯乙烯聚合工人 在最近15 年內結婚，本研究第一年完成了93 位配 偶的面訪問卷；初步資料分析僅在高暴露（大於5 ppm ）有較低的相對受孕比。至於異常出生結果研 究部份亦是一回溯性世代研究，主要探討男性氯乙 烯聚合工人下一代異常出生結果如低出生體重 兒、早產兒、及先天缺陷等，在目前已完成的資料 連鎖中，在1978 至1997 年男性工人配偶共有4,706 位活產嬰兒，發現暴露組有10 位新生而死亡及15 位嬰兒死亡發生而非暴露組並無任何嬰兒死亡個 案發生。但在648 位有暴露資訊的嬰兒中，並無較高的低出生嬰兒或早產兒危險性發生。Although there were several published works on abnormal liver functions, liver cirrhosis or cancer, and genetic damages of Taiwan polyvinyl chloride (PVC) cohort, the potential effect of vinyl chloride monomer (VCM) exposure on reproduction has not yet been studied. Male VCM-exposed workers have been reported loss of libido and reduced spermatogenesis but the effect of male VCM exposure on next generation was inconclusive. Now it is a chance to investigate the effect of male VCM exposure on fecundability measured by time to pregnancy and adverse birth outcomes in Taiwan PVC cohort. This study includes two sub-studies: time-to- pregnancy and adverse birth outcome. The time-to-pregnancy sub-study is designed as a retrospective cohort study to investigate fecundability measured by waiting time to pregnancy and pregnancy outcomes such as spontaneous abortion and stillbirth among the wives of male PVC workers. We recruited 416 valid male workers that married within recent 15 years according to Taiwan marriage registration database. In the first year of this study, 93 wives of male PVC workers participated and finished a face-to-face questionnaire interview. The current analysis consisted of 210 valid pregnancies only. In the preliminary analysis, we found that relative fecundability ratio of the high exposed group (more than 5 ppm) was less than that of non-exposed group although it is not statistically significant. The adverse birth outcome sub-study is designed as a retrospective cohort study to investigate adverse birth outcomes such as low birth weight, prematurity, and infant death with congenital anomalies among the offspring of male PVC workers. We utilized 3925 male PVC workers that have valid national identification numbers to link Taiwan birth registration database during 1978-97. A total of 4,706 livebirths was identified to assess adverse birth outcomes among the offspring of male polyvinyl chloride workers. There were nine newborn deaths and 14 infant deaths among exposed group with unknown exposure level but no case was found in the non-exposed group. However, we could not analyze them further due to few infant deaths. Among 648 births with known exposure level, there was no significant difference among different exposure groups, either by exposure levels or duration of employment.application/pdf75502 bytesapplication/pdfzh-TW國立臺灣大學公共衛生學院職業醫學與工業衛生研究所氯乙烯單體世代研究受孕所需時間自然流產死產低出生體重兒早產兒先天缺陷基因多形性vinyl chloride monomercohort studiestime to pregnancyinfant deathlow birth weightpreterm birth[SDGs]SDG3reporthttp://ntur.lib.ntu.edu.tw/bitstream/246246/4954/1/902320B002124.pdf