2009-03-182024-05-14https://scholars.lib.ntu.edu.tw/handle/123456789/657116摘要：自1945年氯四環黴素被發現後，由於其兼具抗菌範圍廣與促進生長的藥效，故四環黴素類的藥品即被大量與廣泛使用，但基於抗藥性細菌的產生、禽畜水產品殘留與公共衛生的考量等相繼發生（發現）與被重視，本類藥物的使用，已有相當的規範。烏骨雞為傳統重要蛋白質來源之ㄧ，但由於其生長期長，基於治療需要與飼養經濟考量，故常見藥物殘留。本研究的目的，在於了解于烏骨雞口服投予脫氧羥四環黴素後之殘留特性。 雞隻將以20 mg/kg計量投予脫氧羥四環黴素，並於10個時間點蒐集所需樣本，血液與肌肉組織樣本將使用LC/MS分析。相關資料亦除可協助類似藥品停藥期與殘留採樣時間點之評估，與提升家禽產品之安全外，更可提供業者遵循以維護其產業的國際競爭力。 <br> Abstract: Since chlortetracycline discovered in 1945, the tetracyclines had been made and used extensively. However, the bacterial resistance, residue within edible tissues, and public health concerns also is rose. Silkie bantam is a valuable meat source. However, the growth period for silk fowl is much longer than regular broiler chicken. For therapeutic and economic reasons, doxycycline becomes one of the easiest residue drugs in Silkie bantam. The purpose of this study is to define the tissues residue characters of single oral administration of doxycycline (20 mg/kg) at Silkie bantam. After doxycycline administration, at least 10 samples will be taken from each chicken at assigned time points. Both blood and muscle samples will be analyzed by LC/MS. These results also can be used to evaluate withdrew period or sampling time of doxycycline and related compounds.脫氧羥四環黴素烏骨雞殘留DoxycyclineSilkie bantamResidue