Huang C.-L.YEN-WEN WUCHIH-CHENG WUHWANG, JUEY-JENJUEY-JENHWANGWEI-SHIUNG YANG2021-03-182021-03-1820151932-6203https://scholars.lib.ntu.edu.tw/handle/123456789/553724Objective Angiopoietin-like protein 2 (ANGPTL2), which is mainly expressed from adipose tissue, is demonstrated to be involved in obesity, metabolic syndrome, and atherosclerosis. Because several adipocytokines are known to be associated with heart failure (HF), here we investigated the association of ANGPTL2 and HF in Taiwanese subjects. Methods and Results A total of 170 symptomatic HF patients and 130 age- and sex-matched controls were enrolled from clinic. The echocardiography was analyzed in each patient, and stress myocardial perfusion study was performed for clinical suspicion of coronary artery disease. Detailed demographic information, medications, and biochemical data were recorded. Circulating adipocytokines, including tumor necrosis factor-alpha (TNF-α), adiponectin, adipocyte fatty acid-binding protein (A-FABP) and ANGPTL2, were analyzed. Compared with the control group subjects, serum ANGPTL2 concentrations were significantly higher in HF group patients. In correlation analyses, ANGPTL2 level was positively correlated to creatinine, fasting glucose, triglyceride, hsCRP, TNF-α, NT-proBNP and A-FABP levels, and negatively correlated with HDL-C and left ventricular ejection fraction. In multiple regression analysis, A-FABP, hsCRP, and HDL-C levels remained as independent predictors for ANGPTL2 level. To determine the association between serum ANGPTL2 concentrations and HF, multivariate logistic regression analyses were performed with subjects divided into tertiles by ANGPTL2 levels. For the subjects with ANGPTL2 levels in the highest tertile, their risk of HF was about 2.97 fold (95% CI = 1.24-7.08, P = 0.01) higher than those in the lowest tertile. Conclusion Our results demonstrate a higher circulating ANGPTL2 level in patients with HF, and the upregulating ANGPTL2 levels might be associated with metabolic derangements and inflammation. ? 2015 Huang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.[SDGs]SDG3adiponectin; amino terminal pro brain natriuretic peptide; angiopoietin; angiopoietin like protein 2; angiotensin receptor antagonist; beta adrenergic receptor blocking agent; C reactive protein; cholesterol; creatinine; dipeptidyl carboxypeptidase inhibitor; diuretic agent; fatty acid binding protein 4; glucose; hemoglobin A1c; high density lipoprotein cholesterol; hydroxymethylglutaryl coenzyme A reductase inhibitor; triacylglycerol; tumor necrosis factor alpha; unclassified drug; angiopoietin; ANGPTL2 protein, human; C reactive protein; FABP4 protein, human; fatty acid binding protein; high density lipoprotein cholesterol; aged; angiocardiography; Article; body mass; cardiovascular risk; cholesterol blood level; controlled study; coronary artery disease; correlation coefficient; creatinine blood level; cross-sectional study; diet restriction; disease association; disease severity; echocardiography; female; heart failure; heart left ventricle ejection fraction; heart left ventricle enddiastolic pressure; heart left ventricle endsystolic volume; heart muscle perfusion; high risk patient; human; left atrial dimension; low risk patient; major clinical study; male; multiple regression; multivariate logistic regression analysis; pathogenesis; prediction; protein analysis; protein blood level; receiver operating characteristic; stress heart muscle perfusion; Taiwanese; triacylglycerol blood level; upregulation; waist circumference; adipose tissue; blood; Cardiovascular Diseases; case control study; demography; heart failure; metabolism; middle aged; pathology; regression analysis; risk factor; Taiwan; very elderly; Adipose Tissue; Aged; Aged, 80 and over; Angiopoietins; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies; Cholesterol, HDL; Demography; Echocardiography; Fatty Acid-Binding Proteins; Female; Heart Failure; Humans; Male; Middle Aged; Regression Analysis; Risk Factors; Taiwanjournal article10.1371/journal.pone.0138678263979852-s2.0-84946926065