Chung C.-J.YEONG-SHIAU PUChen Y.-T.Su C.-T.Wu C.-C.Shiue H.-S.CHAO-YUAN HUANGHsueh Y.-M.2021-02-022021-02-0220110048-9697https://www.scopus.com/inward/record.uri?eid=2-s2.0-78751704792&doi=10.1016%2fj.scitotenv.2010.11.037&partnerID=40&md5=77582aea0b34b7e43e7dcc6c214eb0b4https://scholars.lib.ntu.edu.tw/handle/123456789/544429Arsenic plays an important role in producing oxidative stress in cultured cells. To investigate the interaction between high oxidative stress and low arsenic methylation capacity on arsenic carcinogenesis, a case-control study was conducted to evaluate the relationship among the indices of oxidative stress, such as urinary 8-hydroxydeoxyquanine (8-OHdG), as well as plasma micronutrients and urinary arsenic profiles on urothelial carcinoma (UC) risk. Urinary 8-OHdG was measured using high-sensitivity enzyme-linked immunosorbent assay kits. The urinary arsenic species were analyzed using high-performance liquid chromatography and hydride generator-atomic absorption spectrometry. Plasma micronutrient levels were analyzed using reversed-phase high-performance liquid chromatography. The present study showed a significant protective effect of plasma alpha-tocopherol on UC risk. Plasma alpha-tocopherol levels were significantly inversely related to urinary total arsenic concentrations and inorganic arsenic percentage (InAs%), and significantly positively related to dimethylarsinic acid percentage (DMA%). There were no correlations between plasma micronutrients and urinary 8-OHdG. Study participants with lower alpha-tocopherol and higher urinary total arsenic, higher InAs%, higher MMA%, and lower DMA% had a higher UC risk than those with higher alpha-tocopherol and lower urinary total arsenic, lower InAs%, lower MMA%, and higher DMA%. These results suggest that plasma alpha-tocopherol might modify the risk of inorganic arsenic-related UC. ? 2010 Elsevier B.V.[SDGs]SDG38-OHdG; Arsenic concentration; Case-control study; Cultured cell; Dimethylarsinic acids; Enzyme linked immunosorbent assay; High-sensitivity; InAs; Inorganic arsenic; Methylation capacity; Micronutrient levels; Protective effects; Reversed phase high performance liquid chromatography; Urinary arsenic; Urothelial carcinoma; Absorption spectroscopy; Atomic absorption spectrometry; Indium arsenide; Liquid chromatography; Liquids; Oxidative stress; Plasmas; Semiconducting indium; Trace elements; Arsenic; 8 hydroxydeoxyguanosine; alpha tocopherol; arsenic; cacodylic acid; trace element; arsenic; carcinogen; concentration (composition); inorganic compound; methylation; plasma; trace element; adult; article; atomic absorption spectrometry; blood analysis; cancer risk; concentration (parameters); controlled study; DNA damage; enzyme linked immunosorbent assay; female; human; male; oxidative stress; priority journal; reversed phase high performance liquid chromatography; risk assessment; transitional cell carcinoma; urinalysis; alpha-Tocopherol; Antioxidants; Arsenic; Carcinogens, Environmental; Carcinoma; Case-Control Studies; DNA Damage; Female; Guanine; Humans; Linear Models; Male; Middle Aged; Multivariate Analysis; Oxidative Stress; Risk Factors; Urologic Neoplasmsjournal article10.1016/j.scitotenv.2010.11.037212274822-s2.0-78751704792