B.-S. YipLiu C.-H.Yen T.-H.JIANN-SHING JENGSung S.-F.Huang P.-H.Li J.-Y.Sun Y.Wei C.-Y.Lien L.-M.Tsai I.-J.Sung F.-C.Hsu C.Y.Liu C.-H.Tsai C.-H.Huang W.-S.Lu C.-T.Tsai T.-C.Tseng C.-H.Lin K.-H.Shyu W.-C.Yang Y.-W.Liu Y.-L.Cho D.-Y.Chen C.-C.SUNG-CHUN TANGLI-KAI TSAISHIN-JOE YEHCHIH-HAO CHENHSIN-HSI TSAIChen H.-J.Lu K.Hsu S.-P.Kuo H.-C.Tsou J.-C.Wang Y.-T.Tai Y.-C.Hsieh M.-T.Liliang P.-C.Liang C.-L.Wang H.-K.Tsai Y.-T.Wang K.-W.Chen J.-S.Chen P.-Y.Wang Y.-C.Sung P.-S.Hsieh H.-C.Su H.-C.Chiu H.-C.Chen W.-H.Bai C.-H.Huang T.-H.Lau C.-I.Wu Y.-Y.Yeh H.-L.Chang A.Lin C.-H.Yen C.-C.Lin R.-T.Khor G.-T.Chao A.-C.Lin H.-F.Huang P.Lin H.-J.Ke D.-S.Chang C.-Y.Yeh P.-S.Lin K.-C.Cheng T.-J.Chou C.-H.Yang C.-M.Shen H.-C.Chen A.-C.Tsai S.-J.Lu T.-M.Kung S.-L.Lee M.-J.Chou H.-H.Chang W.-L.Chiu P.-Y.Hsu M.-H.Chan P.-C.Pan C.-H.Shoung H.-M.Lo Y.-C.Wang F.-H.Chang W.-C.Lai T.-C.Yin J.-H.Wang C.-J.Wang K.-C.Chen L.-M.Denq J.-C.Lu C.-J.Huang C.-C.Chan H.-F.Lee S.-P.Sun M.-H.Ke L.-Y.Chen P.-L.Lee Y.-S.Ong C.-T.Wu C.-S.Hsu Y.-C.Su Y.-H.Hung L.-C.Lee J.-T.Lin J.-C.Hsu Y.-D.Peng G.-S.Hsu C.-H.Lin C.-C.Yen C.-H.Cheng C.-A.Sung Y.-F.Chen Y.-L.Lien M.-T.Liu C.-C.Yang F.-C.Wu Y.-C.Tso A.-C.Lai Y.-H.Chiang C.-I.Tsai C.-K.Liu M.-T.Lin Y.-C.Chiang T.-R.Liao P.-W.Lee M.-C.Chen J.-T.Lie S.-K.Sun M.-C.Hsiao P.-J.Chen W.-L.Chen T.-C.Chang C.-S.Lai C.-H.Chuang C.-S.Chen Y.-Y.Lin S.-K.Su Y.-C.Shiao J.-L.Yang F.-Y.Liu C.-Y.Chiang H.-L.Chen G.-C.Hsu P.-J.Lin I.-S.Chien C.-H.Chang Y.-C.Chen P.-K.Hsiao Y.-J.Fang C.-W.Chen Y.-W.Lee K.-Y.Lin Y.-Y.Li C.-H.Tsai H.-F.Hsieh C.-F.Yang C.-D.Liaw S.-J.Liao H.-C.Wu L.-L.Hsieh L.-P.Lee Y.-H.Chen C.-W.Hsu C.-S.Jhih Y.-J.Zhuang H.-Y.Pan Y.-H.Shih S.-A.Chen C.-I.Sung J.-Y.Weng H.-Y.Teng H.-W.Lee J.-E.Huang C.-S.Chao S.-P.Yuan R.-Y.Sheu J.-J.Yu J.-M.Ho C.-S.Lin T.-C.Yu S.-C.Chen J.-R.Tsai S.-Y.Wei C.-Y.Hung C.-H.Lee C.F.Yang S.-K.Chen C.-L.Lin W.Tseng H.-P.Lin C.-L.Lin H.-C.Chen P.-T.Hu C.-J.Chan L.Chi N.-F.Chern C.-M.Lin C.-J.Wang S.-J.Hsu L.-C.Wong W.-J.Lee I.-H.Yen D.-J.Tsai C.-P.Kwan S.-Y.Soong B.-W.Chen S.-P.Liao K.-K.Lin K.-P.Chen C.Shan D.-E.Fuh J.-L.Wang P.-N.Lee Y.-C.Yu Y.-H.Huang H.-C.Tsai J.-Y.Wu M.-H.Chiang S.-Y.Wang C.-Y.Hsu M.-C.Yeh P.-Y.Wang K.-Y.Chen T.-S.Hsieh C.-Y.Chen W.-F.Yip P.-K.Wang V.Tsai C.-F.Chen C.-C.Liu Y.-C.Chen S.-Y.Zhao Z.-H.Wei Z.-P.Wu S.-L.Liu C.-K.Lin R.-H.Chu C.-H.Yan S.-H.Hsiao S.-H.Yip B.-S.Tsai P.-C.Chou P.-C.Kuo T.-M.Chiu Y.-P.Tsai K.-C.Liao Y.-S.Tsai M.-J.Kao H.-Y.2021-12-222021-12-222018-02-01219150https://www.scopus.com/inward/record.uri?eid=2-s2.0-85039456839&doi=10.1016%2fj.atherosclerosis.2017.11.029&partnerID=40&md5=dd6a229f258b1330d3546b3c5a330508https://scholars.lib.ntu.edu.tw/handle/123456789/590441Background and aims: Renal dysfunction is a potent risk factor for cardiovascular diseases, including stroke. This study aimed to evaluate the impact of admission estimated glomerular filtration rate (eGFR) levels on short-term (1-month) and long-term (1-year) mortality in patients with acute ischemic stroke. Methods: From the Taiwan Stroke Registry data, we classified ischemic stroke patients, identified from April 2006 to December 2015, into 5 groups by eGFR at admission: ? 90, 60–89, 30–59, 15–29, and <15 mL/min/1.73 m2 or on dialysis. Risks of 1-month mortality and 1-year mortality after ischemic stroke were investigated by the eGFR level. Results: Among 52,732 ischemic stroke patients, 1480 died within one month. The 1-month mortality rate was over 5-fold greater in patients with eGFR <15 mL/min/1.73 m2 or dialysis than in patients with eGFR ?90 mL/min/1.73 m2 (2.88 versus 0.56 per 1000 person-days). The adjusted hazard ratio (HR) of 1-month mortality increased from 1.31 (95% CI = 1.08–1.59) for patients with eGFR 60–89 mL/min/1.73 m2 to 2.33 (95% CI = 1.80–3.02) for patients with eGFR < 15 mL/min/1.73 m2 or on dialysis. 3226 patients died within one year. The adjusted HR of mortality increased from 1.38 (95% CI = 1.21–1.59) for patients with eGFR 60–89 mL/min/1.73 m2 to 2.60 (95% CI 2.18–3.10) for patients with eGFR < 15 mL/min/1.73 m2 or on dialysis, compared to patients with eGFR ? 90 mL/min/1.73 m2. Conclusions: After acute ischemic stroke, patients with reduced eGFR are at elevated risks of short-term and long-term deaths in a graded relationship. ? 2017 Elsevier B.V.[SDGs]SDG3cholesterol; hemoglobin; adult; aged; Article; atrial fibrillation; blood pressure; body mass; brain ischemia; chronic kidney failure; congestive cardiomyopathy; diabetes mellitus; estimated glomerular filtration rate; female; hazard ratio; hemodialysis; hospital admission; human; ischemic heart disease; major clinical study; male; mortality; priority journal; smoking; survival rate; Taiwan; very elderly; adolescent; brain ischemia; cerebrovascular accident; clinical trial; epidemiology; glomerulus filtration rate; kidney; kidney disease; middle aged; multicenter study; pathophysiology; prognosis; register; retrospective study; risk assessment; risk factor; time factor; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Brain Ischemia; Female; Glomerular Filtration Rate; Humans; Kidney; Kidney Diseases; Male; Middle Aged; Prognosis; Registries; Retrospective Studies; Risk Assessment; Risk Factors; Stroke; Taiwan; Time Factors; Young Adultjournal article10.1016/j.atherosclerosis.2017.11.029292546922-s2.0-85039456839