醫工所CHIU, CHEN-HUANCHEN-HUANCHIULO, YU-CHUNYU-CHUNLOTANG, HWA-SHENGHWA-SHENGTANGLIU, I-CHAOI-CHAOLIUCHIANG, WEN-YANGWEN-YANGCHIANGYEH, FANG-CHENGFANG-CHENGYEHJAW, FU-SHANFU-SHANJAWTSENG, WEN-YIHWEN-YIHTSENG曾文毅2012-07-132018-06-292012-07-132018-06-292011http://ntur.lib.ntu.edu.tw//handle/246246/241988Previous studies have reported white matter abnormalities in patients with obsessive-compulsive disorder OCD. This study aimed to further explore white matter abnormalities in OCD patients through diffusion spectrum imaging DSI and tractography of the two white matter tracts which most probably play an important role in OCD neuropathology: the anterior segment of cingulum bundles ACB and the anterior thalamic radiations ATR. Twelve right-handed, medicated adult patients with OCD and 12 matched controls underwent DSI on a 3 tesla magnetic resonance imaging MRI system. Tractography based on DSI data was reconstructed to define the ACB and ATR. Mean generalized fractional anisotropy GFA was calculated for each targeted tract and was used to analyze local changes in microstructural integrity along individual tracts. There was a significantly lower mean GFA in both the right ATR and left ACB in OCD subjects compared to controls. OCD subjects also demonstrated decreased left- lateralized asymmetry of the ACB when compared to controls. Furthermore, the mean GFA of the left ACB positively correlated with OCD subjects obsessive subscores on the Yale -Brown Obsessive-Compulsive scale. This study supports the white matter abnormalities in the ACB and ATR of OCD subjects , which corroborates neurobiological models that posit a defect in fronto- striato-thalamic circuitry in OCD.en-USCingulum bundleAnterior thalamic radiationGeneralized fractional anisotropy