2020-08-012024-05-18https://scholars.lib.ntu.edu.tw/handle/123456789/701266憂鬱症是造成慢性病患失能的重要導因，而重度憂鬱症往往長期影響個人的社會功能與社區融入的能力，且對家庭功能造成重大影響，尤以慢性、難治的憂鬱症 (TRD)患者家庭之影響最鉅。過去文獻中對於難治型憂鬱症(Treatment-resistant depression, TRD)精神病理及治療已有一些實證發展，但較少針對憂鬱症之家庭互 動及家屬進行研析；然而，研究團隊執行106-109年科技部TRD非藥物介入策略的研究中發現 : 家庭成員經常是導致TRD個案病情起伏或自殺意念的原因。本計畫目的在於觀察TRD個案之主要家庭成員對病患精神病理症狀發展及預後之影響，研究團隊將先聯繫一群過去已建立之TRD個案族群 (Cohort)的主要家庭成員(Primary Family Members, PFMs)，同步收另一家人(nonPFMs)作為控制組。研究將收集有關TRD病患-家人間互動歷程暨家庭功能之影響，並進行文獻對照、與TRD家庭成員之焦點團體及家庭問卷訪視。 Depression is a main cause of disability among chronic patients. Those with major depressive disorder are prone to have long term effects on the levels of social functioning and community integration, which significantly impairs the family functioning. In particular, families with individuals suffering from chronic depression or treatment-resistant depression (TRD) have the most influences. Previous studies have identified the psychopathology and clinical treatments of TRD, but those focused on the family dynamics and family members of TRD were scarce. A longitudinal study of group-based psychosocial intervention for TRD conducted between 2017-2020 by the principle investigator’s research team found that the family members of TRD might potentially increase the risks of emotional fluctuations or suicidal ideation of the patients. This study aims to identify whether the primary family members (PFMs) have any influences on the development of psychopathological symptoms and prognosis of TRD. The research team will begin with identifying the PFMs who have closest relationship or who may spend the most time or affect the treatment of the TRD patients collected from our previous study, and another non-primary family member as the controls (nonPFMs). The investigation will profile the TRD family functioning and the patient-family dyadic interactions across time through focus group discussions and questionnaire survey in order to collect data and compare to the literature.難治型憂鬱症家庭預後Treatment-resistant depressionfamilyprognosis