王大銘2006-07-252018-06-282006-07-252018-06-281999http://ntur.lib.ntu.edu.tw//handle/246246/9190本計劃在理論及實驗兩方面就膨潤現 象對藥物在高分子膜中擴散的影響進行探 討。在理論推導方面，以Flory-Huggins 及 Yasuda 之理論為基礎，將擴散係數之對數值 展開為膨潤劑活性係數(activity)之冪級函 數，同時，亦可將其表示為膨潤劑在膜中體 積分率的冪級函數。實驗方面則量測透過物 在膜中的擴散係數。所使用之膜材為聚乙烯 乙烯酸酯(EVAc)及聚胺基甲酸酯(PU)兩 種。膨潤劑為乙醇，並加入純水來調整乙醇 之活性係數以及其膨潤能力，並量測 Benzocaine 及NTG 兩種藥物和乙醇之擴散 係數。經由分析實驗結果可發現，擴散係數 之對數值會隨著乙醇活性係數之增加而呈 線性遞增之趨勢，而以體積分率來描述，則 呈現曲線關係。由此可知，以活性係數來描 述膨潤效應對擴散係數之影響，似較以體積分率更為簡便。In the present work, the effect of membrane swelling on the diffusivity of drugs was investigated theoretically and experimentally. On basis of the Flory-Huggins and Yasuda theories, a perturbation procedure was used to expand the logarithm of diffusivity in powers of the activity of swelling agent. Similarly, the logarithm of diffusivity can also be expressed in powers of the volume fraction of swelling agent in the swollen membrane. In addition, experiments of measuring the diffusivity of drugs were performed. The membrane used was the poly(ethylene-co-vinylacetate) and poly-urethane membranes. The swelling agent was ethanol, and water was added to adjust the activity of ethanol and the swelling ability. The diffusivities of benzocaine, nitroglycerin, and ethanol were measured. It was found that the logarithm of the measured diffusivity increases linearly with increasing ethanol activity. On the other hand, for the dependence of the logarithm of diffusivity on the volume fraction of ethanol, the quadratic term is required to bring about good agreement between experimental data and theoretical calculation. Therefore, it seems more convenient to use the dependence of diffusivity on the activity of swelling agent than to use the dependence on the volume fraction of the swelling agent.application/pdf57274 bytesapplication/pdfzh-TW國立臺灣大學化學工程學系暨研究所控制釋放膨潤擴散高分子膜藥物輸送controlled releaseswellingdiffusionpolymeric membranedrug transportreporthttp://ntur.lib.ntu.edu.tw/bitstream/246246/9190/1/882214E002003.pdf