Genetic Variants of TCF7L2 Are Associated with Insulin Resistance and Related Metabolic Phenotypes in Taiwanese Adolescents and Caucasian Young Adults

Liu P.-H.YI-CHENG CHANGYI-DER JIANGWEI J. CHENTIEN-JYUN CHANGKuo S.-S.Lee K.-C.Hsiao P.-C.Chiu K.-C.LEE-MING CHUANG2023-02-082023-02-0820090021-972Xhttps://scholars.lib.ntu.edu.tw/handle/123456789/627698https://www.scopus.com/inward/record.uri?eid=2-s2.0-69949111930&doi=10.1210%2fjc.2009-0609&partnerID=40&md5=3ec674575348b5ccd0489f6b853b7053The effect of TCF7L2 rs7903146 on glucose homeostasis is considered primarily due to impaired insulin secretion in European populations. Because we previously demonstrated that TCF7L2 rs290487 near the 3' end of TCF7L2 was significantly associated with type 2 diabetes (T2D) in Taiwanese subjects, we aimed to investigate potential mechanisms underlying the associations of rs290487 with T2D.enBETA-CELL FUNCTION; TRANSCRIPTION FACTOR; DIABETES PREVENTION; ADIPOSE-TISSUE; GLUCOSE; POLYMORPHISMS; SENSITIVITY; EXPRESSION; SECRETION; RISKGenetic Variants of TCF7L2 Are Associated with Insulin Resistance and Related Metabolic Phenotypes in Taiwanese Adolescents and Caucasian Young Adultsjournal article10.1210/jc.2009-0609195091022-s2.0-69949111930WOS:000269584600059https://api.elsevier.com/content/abstract/scopus_id/69949111930